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PTP1B inhibitor alleviates deleterious microglial activation and neuronal injury after ischemic stroke by modulating the ER stress-autophagy axis via PERK signaling in microglia

Cerebral ischemia/reperfusion (IR) after ischemic stroke causes deleterious microglial activation. Protein tyrosine phosphatase 1B (PTP1B) exacerbates neuroinflammation, yet the effect of the inhibition on microglial activation and cerebral IR injury is unknown. A cerebral IR rat model was induced b...

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Detalles Bibliográficos
Autores principales:	Zhu, Yu, Yu, Jianbo, Gong, Jiangbiao, Shen, Jie, Ye, Di, Cheng, Dexin, Xie, Zhikai, Zeng, Jianping, Xu, Kangli, Shen, Jian, Zhou, Hengjun, Weng, Yuxiang, Pan, Jianwei, Zhan, Renya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906217/ https://www.ncbi.nlm.nih.gov/pubmed/33495405 http://dx.doi.org/10.18632/aging.202272

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