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SARS-CoV-2 associated viral encephalitis with mortality outcome

BACKGROUND: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) appeared in Wuhan, China, in December 2019; apart from common conditions such as cough, fever, and severe respiratory complications, difficulty in breathing, including tachypnea, new studies on neurological manifestations have...

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Detalles Bibliográficos
Autores principales: Azab, Mohammed A., Azzam, Ahmed Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906535/
https://www.ncbi.nlm.nih.gov/pubmed/33654659
http://dx.doi.org/10.1016/j.inat.2021.101132
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author Azab, Mohammed A.
Azzam, Ahmed Y.
author_facet Azab, Mohammed A.
Azzam, Ahmed Y.
author_sort Azab, Mohammed A.
collection PubMed
description BACKGROUND: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) appeared in Wuhan, China, in December 2019; apart from common conditions such as cough, fever, and severe respiratory complications, difficulty in breathing, including tachypnea, new studies on neurological manifestations have gained public interest. CASE REPORT: An 89-year-old man was admitted to the neurocritical care department in a specialized hospital with headache, dizziness, hyperpyrexia, myalgia, rash, and tremors. MRI showed viral encephalitis near to basal ganglia and thalami. DISCUSSION: Coronaviruses interfere with target cells by membrane-bound spike proteins. Angiotensin-converting enzyme 2 was identified as an input receptor for SARS-CoV-2. Due to its wide pattern of expression, COVID-19 was shown to affect several organs, including the central nervous system, where the receptor is mainly expressed as neurons. CONCLUSIONS: In the current pandemic, there is a rising number of global infections, the aim of our case to increase the awareness about SARS-CoV-2 possible complications, even if there are possible further mutations for the virus, especially in the central nervous system.
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spelling pubmed-79065352021-02-26 SARS-CoV-2 associated viral encephalitis with mortality outcome Azab, Mohammed A. Azzam, Ahmed Y. Interdiscip Neurosurg Case Reports & Case Series BACKGROUND: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) appeared in Wuhan, China, in December 2019; apart from common conditions such as cough, fever, and severe respiratory complications, difficulty in breathing, including tachypnea, new studies on neurological manifestations have gained public interest. CASE REPORT: An 89-year-old man was admitted to the neurocritical care department in a specialized hospital with headache, dizziness, hyperpyrexia, myalgia, rash, and tremors. MRI showed viral encephalitis near to basal ganglia and thalami. DISCUSSION: Coronaviruses interfere with target cells by membrane-bound spike proteins. Angiotensin-converting enzyme 2 was identified as an input receptor for SARS-CoV-2. Due to its wide pattern of expression, COVID-19 was shown to affect several organs, including the central nervous system, where the receptor is mainly expressed as neurons. CONCLUSIONS: In the current pandemic, there is a rising number of global infections, the aim of our case to increase the awareness about SARS-CoV-2 possible complications, even if there are possible further mutations for the virus, especially in the central nervous system. The Author(s). Published by Elsevier B.V. 2021-09 2021-02-25 /pmc/articles/PMC7906535/ /pubmed/33654659 http://dx.doi.org/10.1016/j.inat.2021.101132 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Reports & Case Series
Azab, Mohammed A.
Azzam, Ahmed Y.
SARS-CoV-2 associated viral encephalitis with mortality outcome
title SARS-CoV-2 associated viral encephalitis with mortality outcome
title_full SARS-CoV-2 associated viral encephalitis with mortality outcome
title_fullStr SARS-CoV-2 associated viral encephalitis with mortality outcome
title_full_unstemmed SARS-CoV-2 associated viral encephalitis with mortality outcome
title_short SARS-CoV-2 associated viral encephalitis with mortality outcome
title_sort sars-cov-2 associated viral encephalitis with mortality outcome
topic Case Reports & Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906535/
https://www.ncbi.nlm.nih.gov/pubmed/33654659
http://dx.doi.org/10.1016/j.inat.2021.101132
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