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Roflumilast Ameliorates Isoflurane-Induced Inflammation in Astrocytes via the CREB/BDNF Signaling Pathway

[Image: see text] Background and purpose: Astrocyte-mediated neuroinflammation plays an important role in anesthetic isoflurane-induced cognitive impairment. Roflumilast, a selective inhibitor of phosphodiesterase-4 (PDE-4) used for the treatment of chronic obstructive pulmonary disease (COPD), has...

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Detalles Bibliográficos
Autores principales:	Zhang, Chunyuan, Xing, Zeting, Tan, Meiyun, Wu, Yanwen, Zeng, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906587/ https://www.ncbi.nlm.nih.gov/pubmed/33644540 http://dx.doi.org/10.1021/acsomega.0c04799

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