Cargando…

An integrative model of cardiometabolic traits identifies two types of metabolic syndrome

Human diseases arise in a complex ecosystem composed of disease mechanisms and the whole-body state. However, the precise nature of the whole-body state and its relations with disease remain obscure. Here we map similarities among clinical parameters in normal physiological settings, including a lar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frishberg, Amit, van den Munckhof, Inge, ter Horst, Rob, Schraa, Kiki, Joosten, Leo AB, Rutten, Joost HW, Iancu, Adrian C, Dregoesc, Ioana M, Tigu, Bogdan A, Netea, Mihai G, Riksen, Niels P, Gat-Viks, Irit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906604/ https://www.ncbi.nlm.nih.gov/pubmed/33507147 http://dx.doi.org/10.7554/eLife.61710

Ejemplares similares

Vasculometabolic and Inflammatory Effects of Aldosterone in Obesity
por: van der Heijden, Charlotte D C C, et al.
Publicado: (2020)

ImmQuant: a user-friendly tool for inferring immune cell-type composition from gene-expression data
por: Frishberg, Amit, et al.
Publicado: (2016)

Sex-Specific Regulation of Inflammation and Metabolic Syndrome in Obesity
por: ter Horst, Rob, et al.
Publicado: (2020)

Linking traits based on their shared molecular mechanisms
por: Oren, Yael, et al.
Publicado: (2015)

Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects
por: de Graaf, Dennis M., et al.
Publicado: (2020)

Superficial vs Deep Subcutaneous Adipose Tissue: Sex-Specific Associations With Hepatic Steatosis and Metabolic Traits
por: Brand, Tessa, et al.
Publicado: (2021)

Relation Between Plasma Proteomics Analysis and Major Adverse Cardiovascular Events in Patients With Stable Coronary Artery Disease
por: Dregoesc, Mihaela Ioana, et al.
Publicado: (2022)

Evidence for Gene-Specific Rather Than Transcription Rate–Dependent Histone H3 Exchange in Yeast Coding Regions
por: Gat-Viks, Irit, et al.
Publicado: (2009)

Exploiting Gene-Expression Deconvolution to Probe the Genetics of the Immune System
por: Steuerman, Yael, et al.
Publicado: (2016)

A statistical framework for revealing signaling pathways perturbed by DNA variants
por: Wilentzik, Roni, et al.
Publicado: (2015)

Significant common environmental effects on leukocyte subpopulations
por: Botzman, Maya, et al.
Publicado: (2018)

Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes
por: Mirea, Andreea-Manuela, et al.
Publicado: (2019)

Exploring Neural Networks and Related Visualization Techniques in Gene Expression Data
por: Wilentzik Müller, Roni, et al.
Publicado: (2020)

Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study
por: Doestzada, Marwah, et al.
Publicado: (2022)

MetaReg: a platform for modeling, analysis and visualization of biological systems using large-scale experimental data
por: Ulitsky, Igor, et al.
Publicado: (2008)

Sex-specific Association Between Adipose Tissue Inflammation and Vascular and Metabolic Complications of Obesity
por: Cossins, Benjamin C, et al.
Publicado: (2023)

Elucidating regulatory mechanisms downstream of a signaling pathway using informative experiments
por: Szczurek, Ewa, et al.
Publicado: (2009)

Understanding Gene Sequence Variation in the Context of Transcription Regulation in Yeast
por: Gat-Viks, Irit, et al.
Publicado: (2010)

A minimum-labeling approach for reconstructing protein networks across multiple conditions
por: Mazza, Arnon, et al.
Publicado: (2014)

POEM: Identifying Joint Additive Effects on Regulatory Circuits
por: Botzman, Maya, et al.
Publicado: (2016)

Dissecting Dynamic Genetic Variation That Controls Temporal Gene Response in Yeast
por: Brodt, Avital, et al.
Publicado: (2014)

Dissection of Influenza Infection In Vivo by Single-Cell RNA Sequencing
por: Steuerman, Yael, et al.
Publicado: (2018)

Trained innate immunity as a mechanistic link between sepsis and atherosclerosis
por: Bekkering, Siroon, et al.
Publicado: (2014)

Cell composition analysis of bulk genomics using single cell data
por: Frishberg, Amit, et al.
Publicado: (2019)

Deregulation upon DNA damage revealed by joint analysis of context-specific perturbation data
por: Szczurek, Ewa, et al.
Publicado: (2011)

An integrative genomics approach identifies KDM4 as a modulator of trained immunity
por: Moorlag, Simone J.C.F.M., et al.
Publicado: (2021)

Microvascular obstruction in acute myocardial infarction: an old and unsolved mystery
por: Marc, Mădălin Constantin, et al.
Publicado: (2019)

Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice
por: Abu‐Toamih Atamni, Hanifa J., et al.
Publicado: (2018)

Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males
por: Cleophas, Maartje C. P., et al.
Publicado: (2019)

Genetic variant in IL-32 is associated with the ex vivo cytokine production of anti-TNF treated PBMCs from rheumatoid arthritis patients
por: Damen, Michelle S. M. A., et al.
Publicado: (2018)

Association of hemoglobin A1C with circulating metabolites in Dutch with European, African Surinamese and Ghanaian background
por: Zhang, Xiang, et al.
Publicado: (2019)

Intravascular leiomyoma with intracardiac extension associated with hepatorenal polycystic disease
por: Dregoesc, Ioana Mihaela, et al.
Publicado: (2018)

Endovascular treatment of an aortic aneurysm and patent ductus arteriosus
por: Balanescu, Serban Mihai, et al.
Publicado: (2018)

Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity
por: Chen, Lianmin, et al.
Publicado: (2020)

Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli
por: Gat-Viks, Irit, et al.
Publicado: (2013)

Regenerating the Injured Spinal Cord at the Chronic Phase by Engineered iPSCs‐Derived 3D Neuronal Networks
por: Wertheim, Lior, et al.
Publicado: (2022)

The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases
por: Jurrjens, Aaron W, et al.
Publicado: (2023)

Sixteen‐Week Physical Activity Intervention in Subjects With Increased Cardiometabolic Risk Shifts Innate Immune Function Towards a Less Proinflammatory State
por: Noz, Marlies P., et al.
Publicado: (2019)

Interacting with chatbots later in life: A technology acceptance perspective in COVID-19 pandemic situation
por: Iancu, Ioana, et al.
Publicado: (2023)

By what molecular mechanisms do social determinants impact cardiometabolic risk?
por: Baumer, Yvonne, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rpmpbvm0cdd2go722ifenecgnd