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The Card1 nuclease provides defence during Type III CRISPR immunity

During the prokaryotic type III CRISPR-Cas immune response, infection triggers the production of cyclic oligoadenylates, which bind and activate CARF domain-containing proteins(1,2). Many type III loci are associated with proteins in which the CARF domain is fused to an endonuclease-like domain(3,4)...

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Detalles Bibliográficos
Autores principales:	Rostøl, Jakob T., Xie, Wei, Kuryavyi, Vitaly, Maguin, Pascal, Kao, Kevin, Froom, Ruby, Patel, Dinshaw J., Marraffini, Luciano A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906951/ https://www.ncbi.nlm.nih.gov/pubmed/33461211 http://dx.doi.org/10.1038/s41586-021-03206-x

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