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Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS
Impulse oscillometry (IOS) allows evaluation of the compartmentalized resistance and reactance of the respiratory system, distinguishing central and peripheral obstruction. The IOS measurements are getting attention in the diagnosis and differentiation of chronic respiratory diseases. However, no da...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907066/ https://www.ncbi.nlm.nih.gov/pubmed/33633234 http://dx.doi.org/10.1038/s41598-021-84028-9 |
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author | dos Santos, Daniele Oliveira Perossi, Larissa Perossi, Jéssica de Souza Simoni, Letícia Helena Holtz, Mayara Moroli, Ricardo Grassi Baddini-Martinez, José Antônio Gastaldi, Ada Clarice |
author_facet | dos Santos, Daniele Oliveira Perossi, Larissa Perossi, Jéssica de Souza Simoni, Letícia Helena Holtz, Mayara Moroli, Ricardo Grassi Baddini-Martinez, José Antônio Gastaldi, Ada Clarice |
author_sort | dos Santos, Daniele Oliveira |
collection | PubMed |
description | Impulse oscillometry (IOS) allows evaluation of the compartmentalized resistance and reactance of the respiratory system, distinguishing central and peripheral obstruction. The IOS measurements are getting attention in the diagnosis and differentiation of chronic respiratory diseases. However, no data are available in the literature to differentiate between COPD and BE using IOS parameters. We aimed to evaluate the feasibility of IOS in the diagnosis of bronchiectasis non-cystic fibrosis (BE) in comparison to COPD. Whole breath, inspiration, expiration, and inspiratory-expiratory difference (Δ) were evaluated based on the IOS parameters: total resistance (R5), central airway resistance (R20), peripheral airway resistance (R5-R20), reactance (X5), reactance area (AX), and resonance frequency (Fres). Fifty-nine subjects (21 Healthy, 19 BE, and 19 COPD) participated in this study. It was observed a significant difference in the comparison of healthy and pulmonary disease groups (BE and COPD) for total breathing (R5-R20, X5, AX, and Fres), inspiratory phase (R5 and R5-R5), and expiratory phase (R5-R20 and X5). The comparison between BE and COPD groups showed significant difference in the expiratory phase for resistance at 5 and 20 Hz and, ΔR5 and ΔR20. The IOS evidenced an increase of R5, R20 and R5-R20 in patients with BE and COPD when compared to healthy subjects. Expiratory measures of IOS revealed increased airway resistance in COPD compared to BE patients who had similar FEV1 measured by spirometry, however, further studies are needed to confirm these differences. |
format | Online Article Text |
id | pubmed-7907066 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79070662021-02-26 Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS dos Santos, Daniele Oliveira Perossi, Larissa Perossi, Jéssica de Souza Simoni, Letícia Helena Holtz, Mayara Moroli, Ricardo Grassi Baddini-Martinez, José Antônio Gastaldi, Ada Clarice Sci Rep Article Impulse oscillometry (IOS) allows evaluation of the compartmentalized resistance and reactance of the respiratory system, distinguishing central and peripheral obstruction. The IOS measurements are getting attention in the diagnosis and differentiation of chronic respiratory diseases. However, no data are available in the literature to differentiate between COPD and BE using IOS parameters. We aimed to evaluate the feasibility of IOS in the diagnosis of bronchiectasis non-cystic fibrosis (BE) in comparison to COPD. Whole breath, inspiration, expiration, and inspiratory-expiratory difference (Δ) were evaluated based on the IOS parameters: total resistance (R5), central airway resistance (R20), peripheral airway resistance (R5-R20), reactance (X5), reactance area (AX), and resonance frequency (Fres). Fifty-nine subjects (21 Healthy, 19 BE, and 19 COPD) participated in this study. It was observed a significant difference in the comparison of healthy and pulmonary disease groups (BE and COPD) for total breathing (R5-R20, X5, AX, and Fres), inspiratory phase (R5 and R5-R5), and expiratory phase (R5-R20 and X5). The comparison between BE and COPD groups showed significant difference in the expiratory phase for resistance at 5 and 20 Hz and, ΔR5 and ΔR20. The IOS evidenced an increase of R5, R20 and R5-R20 in patients with BE and COPD when compared to healthy subjects. Expiratory measures of IOS revealed increased airway resistance in COPD compared to BE patients who had similar FEV1 measured by spirometry, however, further studies are needed to confirm these differences. Nature Publishing Group UK 2021-02-25 /pmc/articles/PMC7907066/ /pubmed/33633234 http://dx.doi.org/10.1038/s41598-021-84028-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article dos Santos, Daniele Oliveira Perossi, Larissa Perossi, Jéssica de Souza Simoni, Letícia Helena Holtz, Mayara Moroli, Ricardo Grassi Baddini-Martinez, José Antônio Gastaldi, Ada Clarice Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS |
title | Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS |
title_full | Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS |
title_fullStr | Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS |
title_full_unstemmed | Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS |
title_short | Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS |
title_sort | comparative evaluation of expiratory airflow limitation between patients with copd and be using ios |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907066/ https://www.ncbi.nlm.nih.gov/pubmed/33633234 http://dx.doi.org/10.1038/s41598-021-84028-9 |
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