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Choriocapillaris microvasculature dysfunction in systemic hypertension
We examined the choriocapillaris microvasculature using a non-invasive swept-source optical coherence tomography angiography (SS-OCTA) in 41 healthy controls and 71 hypertensive patients and determined possible correlations with BP and renal parameters. BP levels, serum creatinine and urine microalb...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907127/ https://www.ncbi.nlm.nih.gov/pubmed/33633311 http://dx.doi.org/10.1038/s41598-021-84136-6 |
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author | Chua, Jacqueline Le, Thu-Thao Tan, Bingyao Ke, Mengyuan Li, Chi Wong, Damon Wing Kee Tan, Anna C. S. Lamoureux, Ecosse Wong, Tien Yin Chin, Calvin Woon Loong Schmetterer, Leopold |
author_facet | Chua, Jacqueline Le, Thu-Thao Tan, Bingyao Ke, Mengyuan Li, Chi Wong, Damon Wing Kee Tan, Anna C. S. Lamoureux, Ecosse Wong, Tien Yin Chin, Calvin Woon Loong Schmetterer, Leopold |
author_sort | Chua, Jacqueline |
collection | PubMed |
description | We examined the choriocapillaris microvasculature using a non-invasive swept-source optical coherence tomography angiography (SS-OCTA) in 41 healthy controls and 71 hypertensive patients and determined possible correlations with BP and renal parameters. BP levels, serum creatinine and urine microalbumin/creatinine ratio (MCR) specimens were collected. The estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. The main outcome was choriocapillaris flow deficits (CFD) metrics (density, size and numbers). The CFD occupied a larger area and were fewer in number in the hypertensive patients with poor BP control (407 ± 10 µm(2); 3260 ± 61) compared to the hypertensives with good BP control (369 ± 5 µm(2); 3551 ± 41) and healthy controls (365 ± 11 µm(2); 3581 ± 84). Higher systolic BP (β = 9.90, 95% CI, 2.86–16.93), lower eGFR (β = − 0.85; 95% CI, − 1.58 to − 0.13) and higher urine MCR (β = 1.53, 95% CI, 0.32–2.78) were associated with larger areas of CFD. Similar significant associations with systolic BP, eGFR and urine MCR were found with number of CFD. These findings highlight the potential role of choriocapillaris imaging using SS-OCTA as an indicator of systemic microvascular abnormalities secondary to hypertensive disease. |
format | Online Article Text |
id | pubmed-7907127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79071272021-02-26 Choriocapillaris microvasculature dysfunction in systemic hypertension Chua, Jacqueline Le, Thu-Thao Tan, Bingyao Ke, Mengyuan Li, Chi Wong, Damon Wing Kee Tan, Anna C. S. Lamoureux, Ecosse Wong, Tien Yin Chin, Calvin Woon Loong Schmetterer, Leopold Sci Rep Article We examined the choriocapillaris microvasculature using a non-invasive swept-source optical coherence tomography angiography (SS-OCTA) in 41 healthy controls and 71 hypertensive patients and determined possible correlations with BP and renal parameters. BP levels, serum creatinine and urine microalbumin/creatinine ratio (MCR) specimens were collected. The estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. The main outcome was choriocapillaris flow deficits (CFD) metrics (density, size and numbers). The CFD occupied a larger area and were fewer in number in the hypertensive patients with poor BP control (407 ± 10 µm(2); 3260 ± 61) compared to the hypertensives with good BP control (369 ± 5 µm(2); 3551 ± 41) and healthy controls (365 ± 11 µm(2); 3581 ± 84). Higher systolic BP (β = 9.90, 95% CI, 2.86–16.93), lower eGFR (β = − 0.85; 95% CI, − 1.58 to − 0.13) and higher urine MCR (β = 1.53, 95% CI, 0.32–2.78) were associated with larger areas of CFD. Similar significant associations with systolic BP, eGFR and urine MCR were found with number of CFD. These findings highlight the potential role of choriocapillaris imaging using SS-OCTA as an indicator of systemic microvascular abnormalities secondary to hypertensive disease. Nature Publishing Group UK 2021-02-25 /pmc/articles/PMC7907127/ /pubmed/33633311 http://dx.doi.org/10.1038/s41598-021-84136-6 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Chua, Jacqueline Le, Thu-Thao Tan, Bingyao Ke, Mengyuan Li, Chi Wong, Damon Wing Kee Tan, Anna C. S. Lamoureux, Ecosse Wong, Tien Yin Chin, Calvin Woon Loong Schmetterer, Leopold Choriocapillaris microvasculature dysfunction in systemic hypertension |
title | Choriocapillaris microvasculature dysfunction in systemic hypertension |
title_full | Choriocapillaris microvasculature dysfunction in systemic hypertension |
title_fullStr | Choriocapillaris microvasculature dysfunction in systemic hypertension |
title_full_unstemmed | Choriocapillaris microvasculature dysfunction in systemic hypertension |
title_short | Choriocapillaris microvasculature dysfunction in systemic hypertension |
title_sort | choriocapillaris microvasculature dysfunction in systemic hypertension |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907127/ https://www.ncbi.nlm.nih.gov/pubmed/33633311 http://dx.doi.org/10.1038/s41598-021-84136-6 |
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