Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model

Primary ovarian insufficiency (POI) is defined as the loss of ovarian function before 40 years of age. It clinically manifests as amenorrhea, infertility, and signs of estrogen insufficiency. POI is frequently induced by chemotherapy. Gonadotoxic chemotherapy reagents damage granulosa cells, which a...

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Detalles Bibliográficos
Autores principales: Park, Hang-soo, Chugh, Rishi Man, El Andaloussi, Abdeljabar, Hobeika, Elie, Esfandyari, Sahar, Elsharoud, Amro, Ulin, Mara, Garcia, Natalia, Bilal, Mahmood, Al-Hendy, Ayman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907146/
https://www.ncbi.nlm.nih.gov/pubmed/33633319
http://dx.doi.org/10.1038/s41598-021-84216-7

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