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Freedom From Seizures Might Be Key to Continuing Occupation After Epilepsy Surgery

Introduction: We hypothesized that epilepsy surgery for adult patients with temporal lobe epilepsy (TLE) who obtained freedom from seizures could provide opportunities for these patients to continue their occupation, and investigated continuity of occupation to test this postulation. Methods: Data w...

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Autores principales: Nozaki, Toshiki, Fujimoto, Ayataka, Yamazoe, Tomohiro, Niimi, Keiko, Baba, Shimpei, Yamamoto, Takamichi, Sato, Keishiro, Enoki, Hideo, Okanishi, Tohru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907155/
https://www.ncbi.nlm.nih.gov/pubmed/33643186
http://dx.doi.org/10.3389/fneur.2021.585191
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author Nozaki, Toshiki
Fujimoto, Ayataka
Yamazoe, Tomohiro
Niimi, Keiko
Baba, Shimpei
Yamamoto, Takamichi
Sato, Keishiro
Enoki, Hideo
Okanishi, Tohru
author_facet Nozaki, Toshiki
Fujimoto, Ayataka
Yamazoe, Tomohiro
Niimi, Keiko
Baba, Shimpei
Yamamoto, Takamichi
Sato, Keishiro
Enoki, Hideo
Okanishi, Tohru
author_sort Nozaki, Toshiki
collection PubMed
description Introduction: We hypothesized that epilepsy surgery for adult patients with temporal lobe epilepsy (TLE) who obtained freedom from seizures could provide opportunities for these patients to continue their occupation, and investigated continuity of occupation to test this postulation. Methods: Data were obtained from patients who had undergone resective surgery for medically intractable TLE between October 2009 and April 2019 in our hospital. Inclusion criteria were as follows: (1) ≥16 years old at surgery; (2) post-operative follow-up ≥12 months; (3) seizure-free period ≥12 months. As a primary outcome, we evaluated employment status before and after surgery, classified into three categories as follows: Level 0, no job; Level 1, students or homemakers (financially supported by a family member); and Level 2, working. Neuropsychological status was also evaluated as a secondary outcome. Results: Fifty-one (87.9%) of the 58 enrolled TLE patients who obtained freedom from seizures after surgery continued working as before or obtained a new job (employment status: Level 2). A significant difference in employment status was identified between before and after surgery (p = 0.007; Wilcoxon signed-rank test). Twenty-eight patients (48.3%) were evaluated for neuropsychological status both before and after surgery. Significant differences in Wechsler Adult Intelligence Scale-III scores were identified between before and after surgery (p < 0.05 each; paired t-test). Conclusion: Seizure freedom could be a factor that facilitates job continuity, although additional data are needed to confirm that possibility. Further investigation of job continuity after epilepsy surgery warrants an international, multicenter study.
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spelling pubmed-79071552021-02-27 Freedom From Seizures Might Be Key to Continuing Occupation After Epilepsy Surgery Nozaki, Toshiki Fujimoto, Ayataka Yamazoe, Tomohiro Niimi, Keiko Baba, Shimpei Yamamoto, Takamichi Sato, Keishiro Enoki, Hideo Okanishi, Tohru Front Neurol Neurology Introduction: We hypothesized that epilepsy surgery for adult patients with temporal lobe epilepsy (TLE) who obtained freedom from seizures could provide opportunities for these patients to continue their occupation, and investigated continuity of occupation to test this postulation. Methods: Data were obtained from patients who had undergone resective surgery for medically intractable TLE between October 2009 and April 2019 in our hospital. Inclusion criteria were as follows: (1) ≥16 years old at surgery; (2) post-operative follow-up ≥12 months; (3) seizure-free period ≥12 months. As a primary outcome, we evaluated employment status before and after surgery, classified into three categories as follows: Level 0, no job; Level 1, students or homemakers (financially supported by a family member); and Level 2, working. Neuropsychological status was also evaluated as a secondary outcome. Results: Fifty-one (87.9%) of the 58 enrolled TLE patients who obtained freedom from seizures after surgery continued working as before or obtained a new job (employment status: Level 2). A significant difference in employment status was identified between before and after surgery (p = 0.007; Wilcoxon signed-rank test). Twenty-eight patients (48.3%) were evaluated for neuropsychological status both before and after surgery. Significant differences in Wechsler Adult Intelligence Scale-III scores were identified between before and after surgery (p < 0.05 each; paired t-test). Conclusion: Seizure freedom could be a factor that facilitates job continuity, although additional data are needed to confirm that possibility. Further investigation of job continuity after epilepsy surgery warrants an international, multicenter study. Frontiers Media S.A. 2021-02-12 /pmc/articles/PMC7907155/ /pubmed/33643186 http://dx.doi.org/10.3389/fneur.2021.585191 Text en Copyright © 2021 Nozaki, Fujimoto, Yamazoe, Niimi, Baba, Yamamoto, Sato, Enoki and Okanishi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Nozaki, Toshiki
Fujimoto, Ayataka
Yamazoe, Tomohiro
Niimi, Keiko
Baba, Shimpei
Yamamoto, Takamichi
Sato, Keishiro
Enoki, Hideo
Okanishi, Tohru
Freedom From Seizures Might Be Key to Continuing Occupation After Epilepsy Surgery
title Freedom From Seizures Might Be Key to Continuing Occupation After Epilepsy Surgery
title_full Freedom From Seizures Might Be Key to Continuing Occupation After Epilepsy Surgery
title_fullStr Freedom From Seizures Might Be Key to Continuing Occupation After Epilepsy Surgery
title_full_unstemmed Freedom From Seizures Might Be Key to Continuing Occupation After Epilepsy Surgery
title_short Freedom From Seizures Might Be Key to Continuing Occupation After Epilepsy Surgery
title_sort freedom from seizures might be key to continuing occupation after epilepsy surgery
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907155/
https://www.ncbi.nlm.nih.gov/pubmed/33643186
http://dx.doi.org/10.3389/fneur.2021.585191
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