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The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas
The management of vestibular schwannoma (VS) with residual tumor following incomplete resection remains controversial and little is known regarding postoperative tumor volume changes. The behavior of residual tumors was analyzed for 111 patients who underwent surgery for newly diagnosed VS between S...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907355/ https://www.ncbi.nlm.nih.gov/pubmed/33633337 http://dx.doi.org/10.1038/s41598-021-84319-1 |
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author | Park, Hun Ho Park, So Hee Oh, Hyeong-Cheol Jung, Hyun-Ho Chang, Jong Hee Lee, Kyu-Sung Chang, Won Seok Hong, Chang-Ki |
author_facet | Park, Hun Ho Park, So Hee Oh, Hyeong-Cheol Jung, Hyun-Ho Chang, Jong Hee Lee, Kyu-Sung Chang, Won Seok Hong, Chang-Ki |
author_sort | Park, Hun Ho |
collection | PubMed |
description | The management of vestibular schwannoma (VS) with residual tumor following incomplete resection remains controversial and little is known regarding postoperative tumor volume changes. The behavior of residual tumors was analyzed for 111 patients who underwent surgery for newly diagnosed VS between September 2006 and July 2017. The postoperative tumor volume changes were assessed during a mean follow-up of 69 months (range 36–147 months). Fifty-three patients underwent imaging surveillance following incomplete resection. There was no residual tumor growth in 44 patients (83%). A significant regression of residual tumor volume was noted in the no growth group at postoperative 1 year (p = 0.028), 2 years (p = 0.012), but not from 3 years onwards. Significant predictors of regrowth were immediate postoperative tumor volume ≥ 0.7 cm(3) (HR 10.5, p = 0.020) and residual tumor location other than the internal auditory canal (IAC) (HR 6.2, p = 0.026). The mean time to regrowth was 33 months (range 5–127 months). The 2-, 5-, and 10-year regrowth-free survival rates were 90.6%, 86.8%, and 83%, respectively. In conclusion, significant residual tumor regression could occur within 2 years for a VS with an immediate postoperative tumor volume less than 0.7 cm(3) or residual tumor in IAC. |
format | Online Article Text |
id | pubmed-7907355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79073552021-03-02 The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas Park, Hun Ho Park, So Hee Oh, Hyeong-Cheol Jung, Hyun-Ho Chang, Jong Hee Lee, Kyu-Sung Chang, Won Seok Hong, Chang-Ki Sci Rep Article The management of vestibular schwannoma (VS) with residual tumor following incomplete resection remains controversial and little is known regarding postoperative tumor volume changes. The behavior of residual tumors was analyzed for 111 patients who underwent surgery for newly diagnosed VS between September 2006 and July 2017. The postoperative tumor volume changes were assessed during a mean follow-up of 69 months (range 36–147 months). Fifty-three patients underwent imaging surveillance following incomplete resection. There was no residual tumor growth in 44 patients (83%). A significant regression of residual tumor volume was noted in the no growth group at postoperative 1 year (p = 0.028), 2 years (p = 0.012), but not from 3 years onwards. Significant predictors of regrowth were immediate postoperative tumor volume ≥ 0.7 cm(3) (HR 10.5, p = 0.020) and residual tumor location other than the internal auditory canal (IAC) (HR 6.2, p = 0.026). The mean time to regrowth was 33 months (range 5–127 months). The 2-, 5-, and 10-year regrowth-free survival rates were 90.6%, 86.8%, and 83%, respectively. In conclusion, significant residual tumor regression could occur within 2 years for a VS with an immediate postoperative tumor volume less than 0.7 cm(3) or residual tumor in IAC. Nature Publishing Group UK 2021-02-25 /pmc/articles/PMC7907355/ /pubmed/33633337 http://dx.doi.org/10.1038/s41598-021-84319-1 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Park, Hun Ho Park, So Hee Oh, Hyeong-Cheol Jung, Hyun-Ho Chang, Jong Hee Lee, Kyu-Sung Chang, Won Seok Hong, Chang-Ki The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas |
title | The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas |
title_full | The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas |
title_fullStr | The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas |
title_full_unstemmed | The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas |
title_short | The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas |
title_sort | behavior of residual tumors following incomplete surgical resection for vestibular schwannomas |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907355/ https://www.ncbi.nlm.nih.gov/pubmed/33633337 http://dx.doi.org/10.1038/s41598-021-84319-1 |
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