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A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide

There is an urgent need for disinfection and sterilization devices accessible to the public that can be fulfilled by innovative strategies for using cold atmospheric pressure plasmas. Here, we demonstrate a successful novel combination of a flexible printed circuit design of a dielectric barrier dis...

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Autores principales: Gershman, Sophia, Harreguy, Maria B., Yatom, Shurik, Raitses, Yevgeny, Efthimion, Phillip, Haspel, Gal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907379/
https://www.ncbi.nlm.nih.gov/pubmed/33633257
http://dx.doi.org/10.1038/s41598-021-84086-z
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author Gershman, Sophia
Harreguy, Maria B.
Yatom, Shurik
Raitses, Yevgeny
Efthimion, Phillip
Haspel, Gal
author_facet Gershman, Sophia
Harreguy, Maria B.
Yatom, Shurik
Raitses, Yevgeny
Efthimion, Phillip
Haspel, Gal
author_sort Gershman, Sophia
collection PubMed
description There is an urgent need for disinfection and sterilization devices accessible to the public that can be fulfilled by innovative strategies for using cold atmospheric pressure plasmas. Here, we demonstrate a successful novel combination of a flexible printed circuit design of a dielectric barrier discharge (flex-DBD) with an environmentally safe chemical reagent for surface decontamination from bacterial contaminants. Flex-DBD operates in ambient air, atmospheric pressure, and room temperature without any additional gas flow at a power density not exceeding 0.5 W/cm(2). The flex-DBD activation of a 3% hydrogen peroxide solution results in the reduction in the bacterial load of a surface contaminant of > 6log(10) in 90 s, about 3log(10) and 2log(10) better than hydrogen peroxide alone or the flex-DBD alone, respectively, for the same treatment time. We propose that the synergy between plasma and hydrogen peroxide is based on the combined action of plasma-generated OH(·) radicals in the hydrogen peroxide solution and the reactive nitrogen species supplied by the plasma effluent. A scavenger method verified a significant increase in OH(·) concentration due to plasma treatment. Novel in-situ FTIR absorption spectra show the presence of O(3), NO(2), N(2)O, and other nitrogen species. Ozone dissolving in the H(2)O(2) solution can effectively generate OH(·) through a peroxone process. The addition of the reactive nitrogen species increases the disinfection efficiency of the hydroxyl radicals and other oxygen species. Hence, plasma activation of a low concentration hydrogen peroxide solution, using a hand-held flexible DBD device results in a dramatic improvement in disinfection.
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spelling pubmed-79073792021-03-02 A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide Gershman, Sophia Harreguy, Maria B. Yatom, Shurik Raitses, Yevgeny Efthimion, Phillip Haspel, Gal Sci Rep Article There is an urgent need for disinfection and sterilization devices accessible to the public that can be fulfilled by innovative strategies for using cold atmospheric pressure plasmas. Here, we demonstrate a successful novel combination of a flexible printed circuit design of a dielectric barrier discharge (flex-DBD) with an environmentally safe chemical reagent for surface decontamination from bacterial contaminants. Flex-DBD operates in ambient air, atmospheric pressure, and room temperature without any additional gas flow at a power density not exceeding 0.5 W/cm(2). The flex-DBD activation of a 3% hydrogen peroxide solution results in the reduction in the bacterial load of a surface contaminant of > 6log(10) in 90 s, about 3log(10) and 2log(10) better than hydrogen peroxide alone or the flex-DBD alone, respectively, for the same treatment time. We propose that the synergy between plasma and hydrogen peroxide is based on the combined action of plasma-generated OH(·) radicals in the hydrogen peroxide solution and the reactive nitrogen species supplied by the plasma effluent. A scavenger method verified a significant increase in OH(·) concentration due to plasma treatment. Novel in-situ FTIR absorption spectra show the presence of O(3), NO(2), N(2)O, and other nitrogen species. Ozone dissolving in the H(2)O(2) solution can effectively generate OH(·) through a peroxone process. The addition of the reactive nitrogen species increases the disinfection efficiency of the hydroxyl radicals and other oxygen species. Hence, plasma activation of a low concentration hydrogen peroxide solution, using a hand-held flexible DBD device results in a dramatic improvement in disinfection. Nature Publishing Group UK 2021-02-25 /pmc/articles/PMC7907379/ /pubmed/33633257 http://dx.doi.org/10.1038/s41598-021-84086-z Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Gershman, Sophia
Harreguy, Maria B.
Yatom, Shurik
Raitses, Yevgeny
Efthimion, Phillip
Haspel, Gal
A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide
title A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide
title_full A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide
title_fullStr A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide
title_full_unstemmed A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide
title_short A low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide
title_sort low power flexible dielectric barrier discharge disinfects surfaces and improves the action of hydrogen peroxide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907379/
https://www.ncbi.nlm.nih.gov/pubmed/33633257
http://dx.doi.org/10.1038/s41598-021-84086-z
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