Therapeutic Hypothermia Inhibits the Classical Complement Pathway in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy

OBJECTIVE: Complement activation is instrumental in the pathogenesis of Hypoxic-ischemic encephalopathy (HIE), a significant cause of neonatal mortality and disability worldwide. Therapeutic hypothermia (HT), the only available treatment for HIE, only modestly improves outcomes. Complement modulatio...

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Detalles Bibliográficos
Autores principales: Shah, Tushar A., Pallera, Haree K., Kaszowski, Cortney L., Bass, William Thomas, Lattanzio, Frank A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907466/
https://www.ncbi.nlm.nih.gov/pubmed/33642979
http://dx.doi.org/10.3389/fnins.2021.616734

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