Loop Diuretics Inhibit Renal Excretion of Trimethylamine N-Oxide

This study demonstrates, for the first time, that renal tubular excretion of trimethylamine N-oxide (TMAO) is inhibited by concomitant loop diuretic administration. The observed marked accumulation in the renal parenchyma, and to lesser extent, plasma, implies differential distributions of TMAO acro...

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Detalles Bibliográficos
Autores principales: Li, Daniel Y., Wang, Zeneng, Jia, Xun, Yan, Di, Shih, Diana M., Hazen, Stanley L., Lusis, Aldons J., Tang, W.H. Wilson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907536/
https://www.ncbi.nlm.nih.gov/pubmed/33665512
http://dx.doi.org/10.1016/j.jacbts.2020.11.010
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author Li, Daniel Y.
Wang, Zeneng
Jia, Xun
Yan, Di
Shih, Diana M.
Hazen, Stanley L.
Lusis, Aldons J.
Tang, W.H. Wilson
author_facet Li, Daniel Y.
Wang, Zeneng
Jia, Xun
Yan, Di
Shih, Diana M.
Hazen, Stanley L.
Lusis, Aldons J.
Tang, W.H. Wilson
author_sort Li, Daniel Y.
collection PubMed
description This study demonstrates, for the first time, that renal tubular excretion of trimethylamine N-oxide (TMAO) is inhibited by concomitant loop diuretic administration. The observed marked accumulation in the renal parenchyma, and to lesser extent, plasma, implies differential distributions of TMAO across various tissues and/or systems as a consequence of efflux channel control. A better understanding of TMAO renal clearance and its potential interactions with current and future therapies in patients with heart failure are warranted.
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spelling pubmed-79075362021-03-03 Loop Diuretics Inhibit Renal Excretion of Trimethylamine N-Oxide Li, Daniel Y. Wang, Zeneng Jia, Xun Yan, Di Shih, Diana M. Hazen, Stanley L. Lusis, Aldons J. Tang, W.H. Wilson JACC Basic Transl Sci Clinical Research This study demonstrates, for the first time, that renal tubular excretion of trimethylamine N-oxide (TMAO) is inhibited by concomitant loop diuretic administration. The observed marked accumulation in the renal parenchyma, and to lesser extent, plasma, implies differential distributions of TMAO across various tissues and/or systems as a consequence of efflux channel control. A better understanding of TMAO renal clearance and its potential interactions with current and future therapies in patients with heart failure are warranted. Elsevier 2021-01-27 /pmc/articles/PMC7907536/ /pubmed/33665512 http://dx.doi.org/10.1016/j.jacbts.2020.11.010 Text en © 2021 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research
Li, Daniel Y.
Wang, Zeneng
Jia, Xun
Yan, Di
Shih, Diana M.
Hazen, Stanley L.
Lusis, Aldons J.
Tang, W.H. Wilson
Loop Diuretics Inhibit Renal Excretion of Trimethylamine N-Oxide
title Loop Diuretics Inhibit Renal Excretion of Trimethylamine N-Oxide
title_full Loop Diuretics Inhibit Renal Excretion of Trimethylamine N-Oxide
title_fullStr Loop Diuretics Inhibit Renal Excretion of Trimethylamine N-Oxide
title_full_unstemmed Loop Diuretics Inhibit Renal Excretion of Trimethylamine N-Oxide
title_short Loop Diuretics Inhibit Renal Excretion of Trimethylamine N-Oxide
title_sort loop diuretics inhibit renal excretion of trimethylamine n-oxide
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907536/
https://www.ncbi.nlm.nih.gov/pubmed/33665512
http://dx.doi.org/10.1016/j.jacbts.2020.11.010
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