Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice

The adipose Nod-like receptor protein 3 (NLRP3) inflammasome initiates insulin resistance; however, the mechanism of inflammasome activation in adipose tissue remains elusive. In this study, homocysteine (Hcy) was found to participate in insulin resistance via a NLRP3 inflammasome-related process. H...

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Autores principales: Li, Jing, Zhang, Heng, Dong, Yongqiang, Wang, Xian, Wang, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907609/
https://www.ncbi.nlm.nih.gov/pubmed/33643070
http://dx.doi.org/10.3389/fphys.2021.628122
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author Li, Jing
Zhang, Heng
Dong, Yongqiang
Wang, Xian
Wang, Guang
author_facet Li, Jing
Zhang, Heng
Dong, Yongqiang
Wang, Xian
Wang, Guang
author_sort Li, Jing
collection PubMed
description The adipose Nod-like receptor protein 3 (NLRP3) inflammasome initiates insulin resistance; however, the mechanism of inflammasome activation in adipose tissue remains elusive. In this study, homocysteine (Hcy) was found to participate in insulin resistance via a NLRP3 inflammasome-related process. Hcy-induced activation of NLRP3 inflammasomes were observed in adipose tissue during the generation of insulin resistance in vivo. This animal model suggests that diets high in omega-3 fatty acids alter serum and adipose lipid profiles, and in this way, omega-3 fatty acids may reduce adipose tissue inflammation and attenuate insulin resistance.
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spelling pubmed-79076092021-02-27 Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice Li, Jing Zhang, Heng Dong, Yongqiang Wang, Xian Wang, Guang Front Physiol Physiology The adipose Nod-like receptor protein 3 (NLRP3) inflammasome initiates insulin resistance; however, the mechanism of inflammasome activation in adipose tissue remains elusive. In this study, homocysteine (Hcy) was found to participate in insulin resistance via a NLRP3 inflammasome-related process. Hcy-induced activation of NLRP3 inflammasomes were observed in adipose tissue during the generation of insulin resistance in vivo. This animal model suggests that diets high in omega-3 fatty acids alter serum and adipose lipid profiles, and in this way, omega-3 fatty acids may reduce adipose tissue inflammation and attenuate insulin resistance. Frontiers Media S.A. 2021-02-12 /pmc/articles/PMC7907609/ /pubmed/33643070 http://dx.doi.org/10.3389/fphys.2021.628122 Text en Copyright © 2021 Li, Zhang, Dong, Wang and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Li, Jing
Zhang, Heng
Dong, Yongqiang
Wang, Xian
Wang, Guang
Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice
title Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice
title_full Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice
title_fullStr Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice
title_full_unstemmed Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice
title_short Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice
title_sort omega-3fas can inhibit the inflammation and insulin resistance of adipose tissue caused by hhcy induced lipids profile changing in mice
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907609/
https://www.ncbi.nlm.nih.gov/pubmed/33643070
http://dx.doi.org/10.3389/fphys.2021.628122
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