Circular RNA in tumor metastasis

Circular RNAs (circRNAs) are a type of endogenous non-coding RNA that were discovered to regulate gene expression through multiple pathways. Metastasis remains one of the biggest obstacles in cancer treatment. In this review, we focus on circRNAs involved in cancer tumorigenesis and metastasis. We p...

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Autores principales: Zhang, Chao, Ding, RongFang, Sun, YiCheng, Huo, Si Tong, He, Alina, Wen, Chang, Chen, HongHao, Du, William W., Lai, WeiNan, Wang, Huijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907675/
https://www.ncbi.nlm.nih.gov/pubmed/33717646
http://dx.doi.org/10.1016/j.omtn.2021.01.032
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author Zhang, Chao
Ding, RongFang
Sun, YiCheng
Huo, Si Tong
He, Alina
Wen, Chang
Chen, HongHao
Du, William W.
Lai, WeiNan
Wang, Huijun
author_facet Zhang, Chao
Ding, RongFang
Sun, YiCheng
Huo, Si Tong
He, Alina
Wen, Chang
Chen, HongHao
Du, William W.
Lai, WeiNan
Wang, Huijun
author_sort Zhang, Chao
collection PubMed
description Circular RNAs (circRNAs) are a type of endogenous non-coding RNA that were discovered to regulate gene expression through multiple pathways. Metastasis remains one of the biggest obstacles in cancer treatment. In this review, we focus on circRNAs involved in cancer tumorigenesis and metastasis. We present recently identified tumor-related circRNAs and discuss their functioning in tumor progression and metastasis. These circRNAs are categorized into different functional mechanisms, including microRNA (miRNA) sponging, protein binding, regulation of host genes, translation of circRNAs, and exosomal circRNAs. Additionally, the indirect functions of circRNAs that regulate epithelial-mesenchymal transition and autophagy are also discussed.
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spelling pubmed-79076752021-03-12 Circular RNA in tumor metastasis Zhang, Chao Ding, RongFang Sun, YiCheng Huo, Si Tong He, Alina Wen, Chang Chen, HongHao Du, William W. Lai, WeiNan Wang, Huijun Mol Ther Nucleic Acids Review Circular RNAs (circRNAs) are a type of endogenous non-coding RNA that were discovered to regulate gene expression through multiple pathways. Metastasis remains one of the biggest obstacles in cancer treatment. In this review, we focus on circRNAs involved in cancer tumorigenesis and metastasis. We present recently identified tumor-related circRNAs and discuss their functioning in tumor progression and metastasis. These circRNAs are categorized into different functional mechanisms, including microRNA (miRNA) sponging, protein binding, regulation of host genes, translation of circRNAs, and exosomal circRNAs. Additionally, the indirect functions of circRNAs that regulate epithelial-mesenchymal transition and autophagy are also discussed. American Society of Gene & Cell Therapy 2021-02-04 /pmc/articles/PMC7907675/ /pubmed/33717646 http://dx.doi.org/10.1016/j.omtn.2021.01.032 Text en © 2021 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Chao
Ding, RongFang
Sun, YiCheng
Huo, Si Tong
He, Alina
Wen, Chang
Chen, HongHao
Du, William W.
Lai, WeiNan
Wang, Huijun
Circular RNA in tumor metastasis
title Circular RNA in tumor metastasis
title_full Circular RNA in tumor metastasis
title_fullStr Circular RNA in tumor metastasis
title_full_unstemmed Circular RNA in tumor metastasis
title_short Circular RNA in tumor metastasis
title_sort circular rna in tumor metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907675/
https://www.ncbi.nlm.nih.gov/pubmed/33717646
http://dx.doi.org/10.1016/j.omtn.2021.01.032
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