Ancestral lysosomal enzymes with increased activity harbor therapeutic potential for treatment of Hunter syndrome

We show the successful application of ancestral sequence reconstruction to enhance the activity of iduronate-2-sulfatase (IDS), thereby increasing its therapeutic potential for the treatment of Hunter syndrome—a lysosomal storage disease caused by impaired function of IDS. Current treatment, enzyme...

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Detalles Bibliográficos
Autores principales: Hendrikse, Natalie M., Sandegren, Anna, Andersson, Tommy, Blomqvist, Jenny, Makower, Åsa, Possner, Dominik, Su, Chao, Thalén, Niklas, Tjernberg, Agneta, Westermark, Ulrica, Rockberg, Johan, Svensson Gelius, Stefan, Syrén, Per-Olof, Nordling, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907806/
https://www.ncbi.nlm.nih.gov/pubmed/33665572
http://dx.doi.org/10.1016/j.isci.2021.102154

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