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Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism

Porphobilinogen deaminase (PBGD), the third enzyme in the heme biosynthesis, catalyzes the sequential coupling of four porphobilinogen (PBG) molecules into a heme precursor. Mutations in PBGD are associated with acute intermittent porphyria (AIP), a rare metabolic disorder. We used Fourier transform...

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Detalles Bibliográficos
Autores principales:	Bustad, Helene J., Kallio, Juha P., Laitaoja, Mikko, Toska, Karen, Kursula, Inari, Martinez, Aurora, Jänis, Janne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907807/ https://www.ncbi.nlm.nih.gov/pubmed/33665570 http://dx.doi.org/10.1016/j.isci.2021.102152

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