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COVID-19 cardiac injury and the use of colchicine

We report a case of cardiac injury in a 46-year-old man affected by COVID-19. The patient presented with shortness of breath and fever. ECG revealed sinus tachycardia with ventricular extrasystoles and T-wave inversion in anterior leads. Troponin T and N-terminal pro B-type natriuretic peptide were...

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Detalles Bibliográficos
Autores principales: Anton-Vazquez, Vanesa, Byrne, Laura, Anderson, Lisa, Hamzah, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907860/
https://www.ncbi.nlm.nih.gov/pubmed/33622757
http://dx.doi.org/10.1136/bcr-2020-241047
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author Anton-Vazquez, Vanesa
Byrne, Laura
Anderson, Lisa
Hamzah, Lisa
author_facet Anton-Vazquez, Vanesa
Byrne, Laura
Anderson, Lisa
Hamzah, Lisa
author_sort Anton-Vazquez, Vanesa
collection PubMed
description We report a case of cardiac injury in a 46-year-old man affected by COVID-19. The patient presented with shortness of breath and fever. ECG revealed sinus tachycardia with ventricular extrasystoles and T-wave inversion in anterior leads. Troponin T and N-terminal pro B-type natriuretic peptide were elevated. Transthoracic echocardiography showed severely reduced systolic function with an estimated left ventricle ejection fraction of 30%. A nasopharingeal swab was positive for SARS-CoV-2. On day 6, 11 days after onset of symptoms, the patient deteriorated clinically with new chest pain and type 1 respiratory failure. Treatment with colchicine 0.5 mg 8-hourly resulted in rapid clinical resolution. This case report highlights how cardiac injury can dominate the clinical picture in COVID-19 infection. The role of colchicine therapy should be further studied to determine its usefulness in reducing myocardial and possibly lung parenchymal inflammatory responses.
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spelling pubmed-79078602021-03-09 COVID-19 cardiac injury and the use of colchicine Anton-Vazquez, Vanesa Byrne, Laura Anderson, Lisa Hamzah, Lisa BMJ Case Rep Case Report We report a case of cardiac injury in a 46-year-old man affected by COVID-19. The patient presented with shortness of breath and fever. ECG revealed sinus tachycardia with ventricular extrasystoles and T-wave inversion in anterior leads. Troponin T and N-terminal pro B-type natriuretic peptide were elevated. Transthoracic echocardiography showed severely reduced systolic function with an estimated left ventricle ejection fraction of 30%. A nasopharingeal swab was positive for SARS-CoV-2. On day 6, 11 days after onset of symptoms, the patient deteriorated clinically with new chest pain and type 1 respiratory failure. Treatment with colchicine 0.5 mg 8-hourly resulted in rapid clinical resolution. This case report highlights how cardiac injury can dominate the clinical picture in COVID-19 infection. The role of colchicine therapy should be further studied to determine its usefulness in reducing myocardial and possibly lung parenchymal inflammatory responses. BMJ Publishing Group 2021-02-23 /pmc/articles/PMC7907860/ /pubmed/33622757 http://dx.doi.org/10.1136/bcr-2020-241047 Text en © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. This article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.https://bmj.com/coronavirus/usage
spellingShingle Case Report
Anton-Vazquez, Vanesa
Byrne, Laura
Anderson, Lisa
Hamzah, Lisa
COVID-19 cardiac injury and the use of colchicine
title COVID-19 cardiac injury and the use of colchicine
title_full COVID-19 cardiac injury and the use of colchicine
title_fullStr COVID-19 cardiac injury and the use of colchicine
title_full_unstemmed COVID-19 cardiac injury and the use of colchicine
title_short COVID-19 cardiac injury and the use of colchicine
title_sort covid-19 cardiac injury and the use of colchicine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907860/
https://www.ncbi.nlm.nih.gov/pubmed/33622757
http://dx.doi.org/10.1136/bcr-2020-241047
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