Cargando…

Assessment of Clinical Benefit of Integrative Genomic Profiling in Advanced Solid Tumors

IMPORTANCE: Use of next-generation sequencing (NGS) to identify clinically actionable genomic targets has been incorporated into routine clinical practice in the management of advanced solid tumors; however, the clinical utility of this testing remains uncertain. OBJECTIVE: To determine which patien...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cobain, Erin F., Wu, Yi-Mi, Vats, Pankaj, Chugh, Rashmi, Worden, Francis, Smith, David C., Schuetze, Scott M., Zalupski, Mark M., Sahai, Vaibhav, Alva, Ajjai, Schott, Anne F., Caram, Megan E. V., Hayes, Daniel F., Stoffel, Elena M., Jacobs, Michelle F., Kumar-Sinha, Chandan, Cao, Xuhong, Wang, Rui, Lucas, David, Ning, Yu, Rabban, Erica, Bell, Janice, Camelo-Piragua, Sandra, Udager, Aaron M., Cieslik, Marcin, Lonigro, Robert J., Kunju, Lakshmi P., Robinson, Dan R., Talpaz, Moshe, Chinnaiyan, Arul M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Medical Association 2021
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907987/ https://www.ncbi.nlm.nih.gov/pubmed/33630025 http://dx.doi.org/10.1001/jamaoncol.2020.7987

Ejemplares similares

Integrative Clinical Genomics of Metastatic Cancer
por: Robinson, Dan R., et al.
Publicado: (2017)

Genomics driven precision oncology in advanced biliary tract cancer improves survival
por: Kumar-Sinha, Chandan, et al.
Publicado: (2023)

Next generation sequencing of extraskeletal myxoid chondrosarcoma
por: Davis, Elizabeth J., et al.
Publicado: (2017)

Urothelial Cancer With Occult Bone Marrow Metastases and Isolated Thrombocytopenia
por: Alva, Ajjai, et al.
Publicado: (2015)

The use of exome capture RNA-seq for highly degraded RNA with application to clinical cancer sequencing
por: Cieslik, Marcin, et al.
Publicado: (2015)

Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response
por: Zhang, Yuping, et al.
Publicado: (2021)

BRAF activating mutations involving the β3-αC loop in V600E-negative anaplastic pleomorphic xanthoastrocytoma
por: Pratt, Drew, et al.
Publicado: (2018)

Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer
por: Parolia, Abhijit, et al.
Publicado: (2019)

Plasmacytoid urothelial carcinoma: a rapid autopsy case report with unique clinicopathologic and genomic profile
por: Simon, Caroline T., et al.
Publicado: (2019)

SPARC expression in patients with high-risk localized soft tissue sarcoma treated on a randomized phase II trial of neo/adjuvant chemotherapy
por: Davis, Elizabeth J., et al.
Publicado: (2016)

The miR-124-Prolyl Hydroxylase P4HA1-MMP1 axis plays a critical role in prostate cancer progression
por: Chakravarthi, Balabhadrapatruni V. S. K., et al.
Publicado: (2014)

Survival Analysis of 1140 Patients with Biliary Cancer and Benefit from Concurrent Renin-Angiotensin Antagonists, Statins, or Aspirin with Systemic Therapy
por: Gunchick, Valerie, et al.
Publicado: (2023)

Mechanistic Support for Combined MET and AR Blockade in Castration-Resistant Prostate Cancer()()
por: Qiao, Yuanyuan, et al.
Publicado: (2016)

A Novel RNA In Situ Hybridization Assay for the Long Noncoding RNA SChLAP1 Predicts Poor Clinical Outcome After Radical Prostatectomy in Clinically Localized Prostate Cancer()()
por: Mehra, Rohit, et al.
Publicado: (2014)

Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy
por: Hovelson, Daniel H., et al.
Publicado: (2017)

Prognostic and Predictive Biomarkers in Adult and Pediatric Gliomas: Toward Personalized Treatment
por: Haynes, Harry R., et al.
Publicado: (2014)

Identification of novel MECOM gene fusion and personalized therapeutic targets through integrative clinical sequencing in secondary acute myeloid leukemia in a patient with severe congenital neutropenia: a case report and literature review
por: Connelly, James A., et al.
Publicado: (2018)

A randomized phase 2 trial of nivolumab, gemcitabine, and cisplatin or nivolumab and ipilimumab in previously untreated advanced biliary cancer: BilT‐01
por: Sahai, Vaibhav, et al.
Publicado: (2022)

The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer
por: Yu, Jindan, et al.
Publicado: (2010)

Evaluation of Tissue PCA3 Expression in Prostate Cancer by RNA in situ Hybridization - A Correlative Study with Urine PCA3 and TMPRSS2-ERG
por: Warrick, Joshua I., et al.
Publicado: (2013)

Supratentorial neurenteric cyst mimicking hydatid cyst: A case report and literature review
por: Arabi, Mohammad, et al.
Publicado: (2013)

Vasculitic Tibial Mononeuropathy Associated with Inherited Immune Dysregulation: A Review of Tibial Mononeuropathies with Electrodiagnostic Considerations
por: Liu, James, et al.
Publicado: (2021)

Identification of Novel PGR-NR4A3 Fusion in Extraskeletal Myxoid Chondrosarcoma and Resultant Patient Benefit From Tamoxifen Therapy
por: Wilbur, H. Catherine, et al.
Publicado: (2022)

Classification and Selection of Biomarkers in Genomic Data Using LASSO
por: Ghosh, Debashis, et al.
Publicado: (2005)

Expanding the reach of HER2-targeted therapies: transformation of an historical paradigm
por: Cobain, Erin F., et al.
Publicado: (2022)

Giant Cell Tumor of Bone: Effect of Longer Dosing Intervals of Denosumab on Tumor Control and Bone-related Complications
por: Jiang, Cindy Y, et al.
Publicado: (2022)

PubMed QUEST: The PubMed Query Search Tool. An informatics tool to aid cancer centers and cancer investigators in searching the PubMed databases
por: Hanauer, David A., et al.
Publicado: (2007)

BETting on a new prostate cancer treatment
por: Asangani, Irfan A, et al.
Publicado: (2014)

Argonaute 2 modulates EGFR–RAS signaling to promote mutant HRAS and NRAS-driven malignancies
por: Siebenaler, Ronald F, et al.
Publicado: (2022)

MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer
por: Chakravarthi, B V S K, et al.
Publicado: (2016)

Differential modulation of the androgen receptor for prostate cancer therapy depends on the DNA response element
por: Kregel, Steven, et al.
Publicado: (2020)

Pathway analysis reveals functional convergence of gene expression profiles in breast cancer
por: Shen, Ronglai, et al.
Publicado: (2008)

Prognostic meta-signature of breast cancer developed by two-stage mixture modeling of microarray data
por: Shen, Ronglai, et al.
Publicado: (2004)

Case report: Immune-mediated meibomian gland dysfunction following pembrolizumab therapy for advanced urothelial carcinoma
por: Nguyen, Charles B., et al.
Publicado: (2022)

Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma
por: Asangani, Irfan A., et al.
Publicado: (2012)

Magnetic resonance imaging of a temporal lobe cerebral amyloidoma()
por: Ogilvie, Jack, et al.
Publicado: (2022)

Gene Fusion Markup Language: a prototype for exchanging gene fusion data
por: Kalyana-Sundaram, Shanker, et al.
Publicado: (2012)

Estrogen receptor mutations and their role in breast cancer progression
por: Alluri, Prasanna G, et al.
Publicado: (2014)

Epigenetics in Prostate Cancer
por: Albany, Costantine, et al.
Publicado: (2011)

A Comparison of Single Molecule and Amplification Based Sequencing of Cancer Transcriptomes
por: Sam, Lee T., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_9c12k26k01682igcd4qj4ollu3