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The application of BH3 mimetics in myeloid leukemias

Execution of the intrinsic apoptotic pathway is controlled by the BCL-2 proteins at the level of the mitochondrial outer membrane (MOM). This family of proteins consists of prosurvival (e.g., BCL-2, MCL-1) and proapoptotic (e.g., BIM, BAD, HRK) members, the functional balance of which dictates the a...

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Detalles Bibliográficos
Autores principales:	Parry, Narissa, Wheadon, Helen, Copland, Mhairi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908010/ https://www.ncbi.nlm.nih.gov/pubmed/33637708 http://dx.doi.org/10.1038/s41419-021-03500-6

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