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Targeting Gut Microbiota to Treat Hypertension: A Systematic Review
While hypertension remains the leading modifiable risk factor for cardiovascular morbidity and mortality, the pathogenesis of essential hypertension remains only partially understood. Recently, microbial dysbiosis has been associated with multiple chronic diseases closely related to hypertension. In...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908114/ https://www.ncbi.nlm.nih.gov/pubmed/33561095 http://dx.doi.org/10.3390/ijerph18031248 |
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author | Palmu, Joonatan Lahti, Leo Niiranen, Teemu |
author_facet | Palmu, Joonatan Lahti, Leo Niiranen, Teemu |
author_sort | Palmu, Joonatan |
collection | PubMed |
description | While hypertension remains the leading modifiable risk factor for cardiovascular morbidity and mortality, the pathogenesis of essential hypertension remains only partially understood. Recently, microbial dysbiosis has been associated with multiple chronic diseases closely related to hypertension. In addition, multiple small-scale animal and human studies have provided promising results for the association between gut microbial dysbiosis and hypertension. Animal models and a small human pilot study, have demonstrated that high salt intake, a risk factor for both hypertension and cardiovascular disease, depletes certain Lactobacillus species while oral treatment of Lactobacilli prevented salt-sensitive hypertension. To date, four large cohort studies have reported modest associations between gut microbiota features and hypertension. In this systematic literature review, we examine the previously reported links between the gut microbiota and hypertension and what is known about the functional mechanisms behind this association. |
format | Online Article Text |
id | pubmed-7908114 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79081142021-02-27 Targeting Gut Microbiota to Treat Hypertension: A Systematic Review Palmu, Joonatan Lahti, Leo Niiranen, Teemu Int J Environ Res Public Health Systematic Review While hypertension remains the leading modifiable risk factor for cardiovascular morbidity and mortality, the pathogenesis of essential hypertension remains only partially understood. Recently, microbial dysbiosis has been associated with multiple chronic diseases closely related to hypertension. In addition, multiple small-scale animal and human studies have provided promising results for the association between gut microbial dysbiosis and hypertension. Animal models and a small human pilot study, have demonstrated that high salt intake, a risk factor for both hypertension and cardiovascular disease, depletes certain Lactobacillus species while oral treatment of Lactobacilli prevented salt-sensitive hypertension. To date, four large cohort studies have reported modest associations between gut microbiota features and hypertension. In this systematic literature review, we examine the previously reported links between the gut microbiota and hypertension and what is known about the functional mechanisms behind this association. MDPI 2021-01-30 2021-02 /pmc/articles/PMC7908114/ /pubmed/33561095 http://dx.doi.org/10.3390/ijerph18031248 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Palmu, Joonatan Lahti, Leo Niiranen, Teemu Targeting Gut Microbiota to Treat Hypertension: A Systematic Review |
title | Targeting Gut Microbiota to Treat Hypertension: A Systematic Review |
title_full | Targeting Gut Microbiota to Treat Hypertension: A Systematic Review |
title_fullStr | Targeting Gut Microbiota to Treat Hypertension: A Systematic Review |
title_full_unstemmed | Targeting Gut Microbiota to Treat Hypertension: A Systematic Review |
title_short | Targeting Gut Microbiota to Treat Hypertension: A Systematic Review |
title_sort | targeting gut microbiota to treat hypertension: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908114/ https://www.ncbi.nlm.nih.gov/pubmed/33561095 http://dx.doi.org/10.3390/ijerph18031248 |
work_keys_str_mv | AT palmujoonatan targetinggutmicrobiotatotreathypertensionasystematicreview AT lahtileo targetinggutmicrobiotatotreathypertensionasystematicreview AT niiranenteemu targetinggutmicrobiotatotreathypertensionasystematicreview |