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Potentially Inappropriate Medication among Older Patients Who Are Frequent Users of Outpatient Services

Aging is accompanied by changes in organ degeneration, and susceptibility to multiple diseases, leading to the frequent occurrence of adverse drug reactions resulting from polypharmacy (PP) and potentially inappropriate medications (PIM) in older patients. This study employs a retrospective cohort d...

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Autores principales: Hsu, Kung-Chuan, Lu, Hai-Lin, Kuan, Chi-Ming, Wu, Jin-Song, Huang, Chyn-Liang, Lin, Pu-Hua, Trezise, Damien, Wang, Tzu-Chueh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908147/
https://www.ncbi.nlm.nih.gov/pubmed/33499419
http://dx.doi.org/10.3390/ijerph18030985
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author Hsu, Kung-Chuan
Lu, Hai-Lin
Kuan, Chi-Ming
Wu, Jin-Song
Huang, Chyn-Liang
Lin, Pu-Hua
Trezise, Damien
Wang, Tzu-Chueh
author_facet Hsu, Kung-Chuan
Lu, Hai-Lin
Kuan, Chi-Ming
Wu, Jin-Song
Huang, Chyn-Liang
Lin, Pu-Hua
Trezise, Damien
Wang, Tzu-Chueh
author_sort Hsu, Kung-Chuan
collection PubMed
description Aging is accompanied by changes in organ degeneration, and susceptibility to multiple diseases, leading to the frequent occurrence of adverse drug reactions resulting from polypharmacy (PP) and potentially inappropriate medications (PIM) in older patients. This study employs a retrospective cohort design and investigates the association of PP with PIM among older patients with high rates of medical utilization. Using records from a national pharmaceutical care database, an experimental group is formed from patients meeting these criteria, who are then offered home pharmaceutical care. Correspondingly, a control group is formed by identifying older patients with regular levels of use of medical services who had been dispensed medications at community pharmacies. Multivariate logistic regression is performed to assess the association between the rate of PIM and variables, including age, gender, and PP. The study finds that experimental PP participants had a higher rate of PIM prescription (odds ratio (OR) = 5.4) than non-PP control participants (all p < 0.001). In clinical practice, additional caution is required to avoid PIMs. Patients engaged in continuously using long-term medication should take precautions in daily life to alleviate related discomforts. Pharmacists should serve as a bridge between patients and physicians to enhance their health and improve their quality of life.
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spelling pubmed-79081472021-02-27 Potentially Inappropriate Medication among Older Patients Who Are Frequent Users of Outpatient Services Hsu, Kung-Chuan Lu, Hai-Lin Kuan, Chi-Ming Wu, Jin-Song Huang, Chyn-Liang Lin, Pu-Hua Trezise, Damien Wang, Tzu-Chueh Int J Environ Res Public Health Article Aging is accompanied by changes in organ degeneration, and susceptibility to multiple diseases, leading to the frequent occurrence of adverse drug reactions resulting from polypharmacy (PP) and potentially inappropriate medications (PIM) in older patients. This study employs a retrospective cohort design and investigates the association of PP with PIM among older patients with high rates of medical utilization. Using records from a national pharmaceutical care database, an experimental group is formed from patients meeting these criteria, who are then offered home pharmaceutical care. Correspondingly, a control group is formed by identifying older patients with regular levels of use of medical services who had been dispensed medications at community pharmacies. Multivariate logistic regression is performed to assess the association between the rate of PIM and variables, including age, gender, and PP. The study finds that experimental PP participants had a higher rate of PIM prescription (odds ratio (OR) = 5.4) than non-PP control participants (all p < 0.001). In clinical practice, additional caution is required to avoid PIMs. Patients engaged in continuously using long-term medication should take precautions in daily life to alleviate related discomforts. Pharmacists should serve as a bridge between patients and physicians to enhance their health and improve their quality of life. MDPI 2021-01-22 2021-02 /pmc/articles/PMC7908147/ /pubmed/33499419 http://dx.doi.org/10.3390/ijerph18030985 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsu, Kung-Chuan
Lu, Hai-Lin
Kuan, Chi-Ming
Wu, Jin-Song
Huang, Chyn-Liang
Lin, Pu-Hua
Trezise, Damien
Wang, Tzu-Chueh
Potentially Inappropriate Medication among Older Patients Who Are Frequent Users of Outpatient Services
title Potentially Inappropriate Medication among Older Patients Who Are Frequent Users of Outpatient Services
title_full Potentially Inappropriate Medication among Older Patients Who Are Frequent Users of Outpatient Services
title_fullStr Potentially Inappropriate Medication among Older Patients Who Are Frequent Users of Outpatient Services
title_full_unstemmed Potentially Inappropriate Medication among Older Patients Who Are Frequent Users of Outpatient Services
title_short Potentially Inappropriate Medication among Older Patients Who Are Frequent Users of Outpatient Services
title_sort potentially inappropriate medication among older patients who are frequent users of outpatient services
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908147/
https://www.ncbi.nlm.nih.gov/pubmed/33499419
http://dx.doi.org/10.3390/ijerph18030985
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