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Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women

Although simultaneous supplementation of iron and folic acid is justified, the potential interactions between these micronutrients and other elements are poorly known. In this study, we aimed to investigate the effect of iron and folic acid supplementation on the levels of selected essential and tox...

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Autores principales: Suliburska, Joanna, Chmurzynska, Agata, Kocylowski, Rafal, Skrypnik, Katarzyna, Radziejewska, Anna, Baralkiewicz, Danuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908542/
https://www.ncbi.nlm.nih.gov/pubmed/33540920
http://dx.doi.org/10.3390/ijerph18031360
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author Suliburska, Joanna
Chmurzynska, Agata
Kocylowski, Rafal
Skrypnik, Katarzyna
Radziejewska, Anna
Baralkiewicz, Danuta
author_facet Suliburska, Joanna
Chmurzynska, Agata
Kocylowski, Rafal
Skrypnik, Katarzyna
Radziejewska, Anna
Baralkiewicz, Danuta
author_sort Suliburska, Joanna
collection PubMed
description Although simultaneous supplementation of iron and folic acid is justified, the potential interactions between these micronutrients and other elements are poorly known. In this study, we aimed to investigate the effect of iron and folic acid supplementation on the levels of selected essential and toxic elements in the serum of micronutrient-deficient young women. A total of 40 women participated in this study and were divided into two groups: study group (n = 23) (with iron and folate deficiency) and control group (n = 17). The study group received iron and folic acid supplements for 3 months. Blood samples were collected at baseline and after the completion of the study period. Women completed a 3-day food intake record. We calculated the body mass index (BMI) of all the participants. Cellular morphology was analyzed in whole blood, and biochemical parameters were determined in serum. Elements were measured in serum by inductively coupled plasma mass spectrometry (ICP-MS). According to our results, in the case of the study group, the supplementation of iron and folic acid restored their levels; however, it caused a significant decrease in the level of zinc, calcium, and magnesium. In the case of the control group, at the end of the study period, there was a marked decrease in the level of iron. Interestingly, there was an increase in the level of arsenic and vanadium in both groups. In conclusion, simultaneous supplementation of iron and folic acid impairs the level of zinc, calcium, and magnesium in women of childbearing age.
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spelling pubmed-79085422021-02-27 Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women Suliburska, Joanna Chmurzynska, Agata Kocylowski, Rafal Skrypnik, Katarzyna Radziejewska, Anna Baralkiewicz, Danuta Int J Environ Res Public Health Article Although simultaneous supplementation of iron and folic acid is justified, the potential interactions between these micronutrients and other elements are poorly known. In this study, we aimed to investigate the effect of iron and folic acid supplementation on the levels of selected essential and toxic elements in the serum of micronutrient-deficient young women. A total of 40 women participated in this study and were divided into two groups: study group (n = 23) (with iron and folate deficiency) and control group (n = 17). The study group received iron and folic acid supplements for 3 months. Blood samples were collected at baseline and after the completion of the study period. Women completed a 3-day food intake record. We calculated the body mass index (BMI) of all the participants. Cellular morphology was analyzed in whole blood, and biochemical parameters were determined in serum. Elements were measured in serum by inductively coupled plasma mass spectrometry (ICP-MS). According to our results, in the case of the study group, the supplementation of iron and folic acid restored their levels; however, it caused a significant decrease in the level of zinc, calcium, and magnesium. In the case of the control group, at the end of the study period, there was a marked decrease in the level of iron. Interestingly, there was an increase in the level of arsenic and vanadium in both groups. In conclusion, simultaneous supplementation of iron and folic acid impairs the level of zinc, calcium, and magnesium in women of childbearing age. MDPI 2021-02-02 2021-02 /pmc/articles/PMC7908542/ /pubmed/33540920 http://dx.doi.org/10.3390/ijerph18031360 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suliburska, Joanna
Chmurzynska, Agata
Kocylowski, Rafal
Skrypnik, Katarzyna
Radziejewska, Anna
Baralkiewicz, Danuta
Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women
title Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women
title_full Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women
title_fullStr Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women
title_full_unstemmed Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women
title_short Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women
title_sort effect of iron and folic acid supplementation on the level of essential and toxic elements in young women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908542/
https://www.ncbi.nlm.nih.gov/pubmed/33540920
http://dx.doi.org/10.3390/ijerph18031360
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