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Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women
Although simultaneous supplementation of iron and folic acid is justified, the potential interactions between these micronutrients and other elements are poorly known. In this study, we aimed to investigate the effect of iron and folic acid supplementation on the levels of selected essential and tox...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908542/ https://www.ncbi.nlm.nih.gov/pubmed/33540920 http://dx.doi.org/10.3390/ijerph18031360 |
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author | Suliburska, Joanna Chmurzynska, Agata Kocylowski, Rafal Skrypnik, Katarzyna Radziejewska, Anna Baralkiewicz, Danuta |
author_facet | Suliburska, Joanna Chmurzynska, Agata Kocylowski, Rafal Skrypnik, Katarzyna Radziejewska, Anna Baralkiewicz, Danuta |
author_sort | Suliburska, Joanna |
collection | PubMed |
description | Although simultaneous supplementation of iron and folic acid is justified, the potential interactions between these micronutrients and other elements are poorly known. In this study, we aimed to investigate the effect of iron and folic acid supplementation on the levels of selected essential and toxic elements in the serum of micronutrient-deficient young women. A total of 40 women participated in this study and were divided into two groups: study group (n = 23) (with iron and folate deficiency) and control group (n = 17). The study group received iron and folic acid supplements for 3 months. Blood samples were collected at baseline and after the completion of the study period. Women completed a 3-day food intake record. We calculated the body mass index (BMI) of all the participants. Cellular morphology was analyzed in whole blood, and biochemical parameters were determined in serum. Elements were measured in serum by inductively coupled plasma mass spectrometry (ICP-MS). According to our results, in the case of the study group, the supplementation of iron and folic acid restored their levels; however, it caused a significant decrease in the level of zinc, calcium, and magnesium. In the case of the control group, at the end of the study period, there was a marked decrease in the level of iron. Interestingly, there was an increase in the level of arsenic and vanadium in both groups. In conclusion, simultaneous supplementation of iron and folic acid impairs the level of zinc, calcium, and magnesium in women of childbearing age. |
format | Online Article Text |
id | pubmed-7908542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79085422021-02-27 Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women Suliburska, Joanna Chmurzynska, Agata Kocylowski, Rafal Skrypnik, Katarzyna Radziejewska, Anna Baralkiewicz, Danuta Int J Environ Res Public Health Article Although simultaneous supplementation of iron and folic acid is justified, the potential interactions between these micronutrients and other elements are poorly known. In this study, we aimed to investigate the effect of iron and folic acid supplementation on the levels of selected essential and toxic elements in the serum of micronutrient-deficient young women. A total of 40 women participated in this study and were divided into two groups: study group (n = 23) (with iron and folate deficiency) and control group (n = 17). The study group received iron and folic acid supplements for 3 months. Blood samples were collected at baseline and after the completion of the study period. Women completed a 3-day food intake record. We calculated the body mass index (BMI) of all the participants. Cellular morphology was analyzed in whole blood, and biochemical parameters were determined in serum. Elements were measured in serum by inductively coupled plasma mass spectrometry (ICP-MS). According to our results, in the case of the study group, the supplementation of iron and folic acid restored their levels; however, it caused a significant decrease in the level of zinc, calcium, and magnesium. In the case of the control group, at the end of the study period, there was a marked decrease in the level of iron. Interestingly, there was an increase in the level of arsenic and vanadium in both groups. In conclusion, simultaneous supplementation of iron and folic acid impairs the level of zinc, calcium, and magnesium in women of childbearing age. MDPI 2021-02-02 2021-02 /pmc/articles/PMC7908542/ /pubmed/33540920 http://dx.doi.org/10.3390/ijerph18031360 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Suliburska, Joanna Chmurzynska, Agata Kocylowski, Rafal Skrypnik, Katarzyna Radziejewska, Anna Baralkiewicz, Danuta Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women |
title | Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women |
title_full | Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women |
title_fullStr | Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women |
title_full_unstemmed | Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women |
title_short | Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women |
title_sort | effect of iron and folic acid supplementation on the level of essential and toxic elements in young women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908542/ https://www.ncbi.nlm.nih.gov/pubmed/33540920 http://dx.doi.org/10.3390/ijerph18031360 |
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