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Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction

Diet deeply impacts brain functions like synaptic plasticity and cognitive processes, neuroendocrine functions, reproduction and behaviour, with detrimental or protective effects on neuronal physiology and therefore consequences for health. In this respect, the activity of metabolic sensors within t...

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Detalles Bibliográficos
Autores principales: D’Angelo, Stefania, Mele, Elena, Di Filippo, Federico, Viggiano, Andrea, Meccariello, Rosaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908627/
https://www.ncbi.nlm.nih.gov/pubmed/33573212
http://dx.doi.org/10.3390/ijerph18031243
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author D’Angelo, Stefania
Mele, Elena
Di Filippo, Federico
Viggiano, Andrea
Meccariello, Rosaria
author_facet D’Angelo, Stefania
Mele, Elena
Di Filippo, Federico
Viggiano, Andrea
Meccariello, Rosaria
author_sort D’Angelo, Stefania
collection PubMed
description Diet deeply impacts brain functions like synaptic plasticity and cognitive processes, neuroendocrine functions, reproduction and behaviour, with detrimental or protective effects on neuronal physiology and therefore consequences for health. In this respect, the activity of metabolic sensors within the brain is critical for the maintenance of health status and represents a possible therapeutic target for some diseases. This review summarizes the main activity of Sirtuin1 (Sirt1), a metabolic sensor within the brain with a focus on the link between the central control of energy homeostasis and reproduction. The possible modulation of Sirt1 by natural phytochemical compounds like polyphenols is also discussed.
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spelling pubmed-79086272021-02-27 Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction D’Angelo, Stefania Mele, Elena Di Filippo, Federico Viggiano, Andrea Meccariello, Rosaria Int J Environ Res Public Health Review Diet deeply impacts brain functions like synaptic plasticity and cognitive processes, neuroendocrine functions, reproduction and behaviour, with detrimental or protective effects on neuronal physiology and therefore consequences for health. In this respect, the activity of metabolic sensors within the brain is critical for the maintenance of health status and represents a possible therapeutic target for some diseases. This review summarizes the main activity of Sirtuin1 (Sirt1), a metabolic sensor within the brain with a focus on the link between the central control of energy homeostasis and reproduction. The possible modulation of Sirt1 by natural phytochemical compounds like polyphenols is also discussed. MDPI 2021-01-30 2021-02 /pmc/articles/PMC7908627/ /pubmed/33573212 http://dx.doi.org/10.3390/ijerph18031243 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
D’Angelo, Stefania
Mele, Elena
Di Filippo, Federico
Viggiano, Andrea
Meccariello, Rosaria
Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction
title Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction
title_full Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction
title_fullStr Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction
title_full_unstemmed Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction
title_short Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction
title_sort sirt1 activity in the brain: simultaneous effects on energy homeostasis and reproduction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908627/
https://www.ncbi.nlm.nih.gov/pubmed/33573212
http://dx.doi.org/10.3390/ijerph18031243
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