Cargando…

Clinical-grade whole-genome sequencing and 3′ transcriptome analysis of colorectal cancer patients

BACKGROUND: Clinical-grade whole-genome sequencing (cWGS) has the potential to become the standard of care within the clinic because of its breadth of coverage and lack of bias towards certain regions of the genome. Colorectal cancer presents a difficult treatment paradigm, with over 40% of patients...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stodolna, Agata, He, Miao, Vasipalli, Mahesh, Kingsbury, Zoya, Becq, Jennifer, Stockton, Joanne D., Dilworth, Mark P., James, Jonathan, Sillo, Toju, Blakeway, Daniel, Ward, Stephen T., Ismail, Tariq, Ross, Mark T., Beggs, Andrew D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908713/ https://www.ncbi.nlm.nih.gov/pubmed/33632293 http://dx.doi.org/10.1186/s13073-021-00852-8

Ejemplares similares

Patient Derived Organoids Confirm That PI3K/AKT Signalling Is an Escape Pathway for Radioresistance and a Target for Therapy in Rectal Cancer
por: Wanigasooriya, Kasun, et al.
Publicado: (2022)

MicroRNA changes in maternal serum from pregnancies complicated by twin‐twin transfusion syndrome: A discovery study
por: Mackie, Fiona L., et al.
Publicado: (2019)

Validation of epigenetic markers to identify colitis associated cancer: Results of module 1 of the ENDCAP-C study
por: Beggs, Andrew D., et al.
Publicado: (2018)

Whole-genome sequencing provides new insights into the clonal architecture of Barrett’s esophagus and esophageal adenocarcinoma
por: Ross-Innes, Caryn S., et al.
Publicado: (2015)

Correction to: Use of an Integrated Pan-Cancer Oncology Enrichment Next-Generation Sequencing Assay to Measure Tumour Mutational Burden and Detect Clinically Actionable Variants
por: Pestinger, Valerie, et al.
Publicado: (2020)

Use of an Integrated Pan-Cancer Oncology Enrichment Next-Generation Sequencing Assay to Measure Tumour Mutational Burden and Detect Clinically Actionable Variants
por: Pestinger, Valerie, et al.
Publicado: (2020)

Whole-Genome Sequencing Can Identify Clinically Relevant Variants from a Single Sub-Punch of a Dried Blood Spot Specimen
por: McBride, David J., et al.
Publicado: (2023)

Whole Genome Methylation Analysis of Nondysplastic Barrett Esophagus that Progresses to Invasive Cancer
por: Dilworth, Mark P., et al.
Publicado: (2019)

Complete response to neoadjuvant chemoradiotherapy in rectal cancer is associated with RAS/AKT mutations and high tumour mutational burden
por: Stockton, Joanne D., et al.
Publicado: (2021)

Mechanisms of immunogenicity in colorectal cancer
por: Sillo, T O, et al.
Publicado: (2019)

The Gut Microbiome, Microsatellite Status and the Response to Immunotherapy in Colorectal Cancer
por: Sillo, Toritseju O., et al.
Publicado: (2023)

Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia
por: Ryan, Sarra L., et al.
Publicado: (2023)

Surgery in the era of the 'omics revolution
por: Beggs, A. D., et al.
Publicado: (2015)

Clinical whole-genome sequencing from routine formalin-fixed, paraffin-embedded specimens: pilot study for the 100,000 Genomes Project
por: Robbe, Pauline, et al.
Publicado: (2018)

Discovery and Validation of Methylation Biomarkers for Ulcerative Colitis Associated Neoplasia
por: Beggs, Andrew D, et al.
Publicado: (2018)

A systematic review of transarterial embolization versus emergency surgery in treatment of major nonvariceal upper gastrointestinal bleeding
por: Beggs, Andrew D, et al.
Publicado: (2014)

Whole genome evaluation of horizontal transfers in the pathogenic fungus Aspergillus fumigatus
por: Mallet, Ludovic V, et al.
Publicado: (2010)

Methylation changes in the TFAP2E promoter region are associated with BRAF mutation and poorer overall & disease free survival in colorectal cancer
por: Beggs, Andrew D., et al.
Publicado: (2015)

A systematic review of epigenetic biomarkers in progression from non-dysplastic Barrett’s oesophagus to oesophageal adenocarcinoma
por: Nieto, Tom, et al.
Publicado: (2018)

Epigenetic biomarkers in progression from non-dysplastic Barrett's oesophagus to oesophageal adenocarcinoma: a systematic review protocol
por: Nieto, T, et al.
Publicado: (2016)

The transition from primary colorectal cancer to isolated peritoneal malignancy is associated with an increased tumour mutational burden
por: Hallam, Sally, et al.
Publicado: (2020)

Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma
por: Raiber, Eun-Ang, et al.
Publicado: (2017)

Radiosensitising Cancer Using Phosphatidylinositol-3-Kinase (PI3K), Protein Kinase B (AKT) or Mammalian Target of Rapamycin (mTOR) Inhibitors
por: Wanigasooriya, Kasun, et al.
Publicado: (2020)

Natural selection drives the fine-scale divergence of a coevolutionary arms race involving a long-mouthed weevil and its obligate host plant
por: Toju, Hirokazu
Publicado: (2009)

Why I Give Preference to Buffalo Lithia over All Other Mineral Waters
por: Sillo, Valdemar
Publicado: (1905)

A deep learning system for prostate cancer diagnosis and grading in whole slide images of core needle biopsies
por: Singhal, Nitin, et al.
Publicado: (2022)

Whole-genome methylation analysis of benign and malignant colorectal tumours
por: Beggs, Andrew D, et al.
Publicado: (2013)

Predicting CFTR activity with front-runner cystic fibrosis drugs
por: Becq, Frédéric
Publicado: (2015)

Familial congenital cataract, coloboma, and nystagmus phenotype with variable expression caused by mutation in PAX6 in a South African family
por: Goolam, Saadiah, et al.
Publicado: (2018)

ClinSV: clinical grade structural and copy number variant detection from whole genome sequencing data
por: Minoche, Andre E., et al.
Publicado: (2021)

Self-generated morphology in lagoon reefs
por: Blakeway, David, et al.
Publicado: (2015)

Deep learning-based breast cancer grading and survival analysis on whole-slide histopathology images
por: Wetstein, Suzanne C., et al.
Publicado: (2022)

Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae
por: Kingsbury, Joanne M., et al.
Publicado: (2015)

Problem-based learning and larger student groups: mutually exclusive or compatible concepts – a pilot study
por: Kingsbury, Martyn P, et al.
Publicado: (2008)

Rapid single-colony whole-genome sequencing of bacterial pathogens
por: Köser, Claudio U., et al.
Publicado: (2014)

Leptin Levels Are Higher in Whole Compared to Skim Human Milk, Supporting a Cellular Contribution
por: Kugananthan, Sambavi, et al.
Publicado: (2016)

Two New Computational Methods for Universal DNA Barcoding: A Benchmark Using Barcode Sequences of Bacteria, Archaea, Animals, Fungi, and Land Plants
por: Tanabe, Akifumi S., et al.
Publicado: (2013)

Correction: Two New Computational Methods for Universal DNA Barcoding: A Benchmark Using Barcode Sequences of Bacteria, Archaea, Animals, Fungi, and Land Plants
por: Tanabe, Akifumi S., et al.
Publicado: (2016)

Root-Associated Fungi Shared Between Arbuscular Mycorrhizal and Ectomycorrhizal Conifers in a Temperate Forest
por: Toju, Hirokazu, et al.
Publicado: (2018)

Consortia of anti-nematode fungi and bacteria in the rhizosphere of soybean plants attacked by root-knot nematodes
por: Toju, Hirokazu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_it8otb3vicj0sd6i4lp620sdpg