The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus

Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of daptomycin resistance in S. aureus is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses ag...

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Autores principales: Bhuiyan, Md Saruar, Jiang, Jhih-Hang, Kostoulias, Xenia, Theegala, Ravali, Lieschke, Graham J., Peleg, Anton Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908987/
https://www.ncbi.nlm.nih.gov/pubmed/33498191
http://dx.doi.org/10.3390/antibiotics10020096
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author Bhuiyan, Md Saruar
Jiang, Jhih-Hang
Kostoulias, Xenia
Theegala, Ravali
Lieschke, Graham J.
Peleg, Anton Y.
author_facet Bhuiyan, Md Saruar
Jiang, Jhih-Hang
Kostoulias, Xenia
Theegala, Ravali
Lieschke, Graham J.
Peleg, Anton Y.
author_sort Bhuiyan, Md Saruar
collection PubMed
description Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of daptomycin resistance in S. aureus is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses against clinically derived, daptomycin-resistant (DAP-R) and -susceptible S. aureus paired isolates using a zebrafish infection model. We showed that the control of DAP-R S. aureus infections was attenuated in vivo due to cross-resistance to host cationic antimicrobial peptides. These data provide mechanistic understanding into persistent infections caused by DAP-R S. aureus and provide crucial insights into the adaptive evolution of this troublesome pathogen.
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spelling pubmed-79089872021-02-27 The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus Bhuiyan, Md Saruar Jiang, Jhih-Hang Kostoulias, Xenia Theegala, Ravali Lieschke, Graham J. Peleg, Anton Y. Antibiotics (Basel) Communication Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of daptomycin resistance in S. aureus is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses against clinically derived, daptomycin-resistant (DAP-R) and -susceptible S. aureus paired isolates using a zebrafish infection model. We showed that the control of DAP-R S. aureus infections was attenuated in vivo due to cross-resistance to host cationic antimicrobial peptides. These data provide mechanistic understanding into persistent infections caused by DAP-R S. aureus and provide crucial insights into the adaptive evolution of this troublesome pathogen. MDPI 2021-01-20 /pmc/articles/PMC7908987/ /pubmed/33498191 http://dx.doi.org/10.3390/antibiotics10020096 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Bhuiyan, Md Saruar
Jiang, Jhih-Hang
Kostoulias, Xenia
Theegala, Ravali
Lieschke, Graham J.
Peleg, Anton Y.
The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus
title The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus
title_full The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus
title_fullStr The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus
title_full_unstemmed The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus
title_short The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus
title_sort resistance to host antimicrobial peptides in infections caused by daptomycin-resistant staphylococcus aureus
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908987/
https://www.ncbi.nlm.nih.gov/pubmed/33498191
http://dx.doi.org/10.3390/antibiotics10020096
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