Cargando…

Using arterial spin labeling blood flow and its histogram analysis to distinguish early-stage nasopharyngeal carcinoma from lymphoid hyperplasia

To investigate the feasibility of arterial spin labeling (ASL) blood flow (BF) and its histogram analysis to distinguish early-stage nasopharyngeal carcinoma (NPC) from nasopharyngeal lymphoid hyperplasia (NPLH). Sixty-three stage T1 NPC patients and benign NPLH patients underwent ASL on a 3.0-T mag...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Bohan, Wang, Peiguo, Zhao, Yingru, Liu, Ying, Ye, Zhaoxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909173/
https://www.ncbi.nlm.nih.gov/pubmed/33663135
http://dx.doi.org/10.1097/MD.0000000000024955
_version_ 1783655873622573056
author Xiao, Bohan
Wang, Peiguo
Zhao, Yingru
Liu, Ying
Ye, Zhaoxiang
author_facet Xiao, Bohan
Wang, Peiguo
Zhao, Yingru
Liu, Ying
Ye, Zhaoxiang
author_sort Xiao, Bohan
collection PubMed
description To investigate the feasibility of arterial spin labeling (ASL) blood flow (BF) and its histogram analysis to distinguish early-stage nasopharyngeal carcinoma (NPC) from nasopharyngeal lymphoid hyperplasia (NPLH). Sixty-three stage T1 NPC patients and benign NPLH patients underwent ASL on a 3.0-T magnetic resonance imaging system. BF histogram parameters were derived automatically, including the mean, median, maximum, minimum, kurtosis, skewness, and variance. Absolute values were obtained for skewness and kurtosis (absolute value of skewness [AVS] and absolute value of kurtosis [AVK], respectively). The Mann–Whitney U test, receiver operating characteristic curve, and multiple logistic regression models were used for statistical analysis. The mean, maximum, and variance of ASL BF values were significantly higher in early-stage NPC than in NPLH (all P < 0.0001), while the median and AVK values of early-stage NPC were also significantly higher than those of NPLH (all P < 0.001). No significant difference was found between the minimum and AVS values in early-stage NPC compared with NPLH (P = 0.125 and P = 0.084, respectively). The area under the curve (AUC) of the maximum was significantly higher than those of the mean and median (P < 0.05). The AUC of variance was significantly higher than those of the other parameters (all P < 0.05). Multivariate analysis showed that variance was the only independent predictor of outcome (P < 0.05). ASL BF and its histogram analysis could distinguish early-stage NPC from NPLH, and the variance value was a unique independent predictor.
format Online
Article
Text
id pubmed-7909173
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-79091732021-03-01 Using arterial spin labeling blood flow and its histogram analysis to distinguish early-stage nasopharyngeal carcinoma from lymphoid hyperplasia Xiao, Bohan Wang, Peiguo Zhao, Yingru Liu, Ying Ye, Zhaoxiang Medicine (Baltimore) 6800 To investigate the feasibility of arterial spin labeling (ASL) blood flow (BF) and its histogram analysis to distinguish early-stage nasopharyngeal carcinoma (NPC) from nasopharyngeal lymphoid hyperplasia (NPLH). Sixty-three stage T1 NPC patients and benign NPLH patients underwent ASL on a 3.0-T magnetic resonance imaging system. BF histogram parameters were derived automatically, including the mean, median, maximum, minimum, kurtosis, skewness, and variance. Absolute values were obtained for skewness and kurtosis (absolute value of skewness [AVS] and absolute value of kurtosis [AVK], respectively). The Mann–Whitney U test, receiver operating characteristic curve, and multiple logistic regression models were used for statistical analysis. The mean, maximum, and variance of ASL BF values were significantly higher in early-stage NPC than in NPLH (all P < 0.0001), while the median and AVK values of early-stage NPC were also significantly higher than those of NPLH (all P < 0.001). No significant difference was found between the minimum and AVS values in early-stage NPC compared with NPLH (P = 0.125 and P = 0.084, respectively). The area under the curve (AUC) of the maximum was significantly higher than those of the mean and median (P < 0.05). The AUC of variance was significantly higher than those of the other parameters (all P < 0.05). Multivariate analysis showed that variance was the only independent predictor of outcome (P < 0.05). ASL BF and its histogram analysis could distinguish early-stage NPC from NPLH, and the variance value was a unique independent predictor. Lippincott Williams & Wilkins 2021-02-26 /pmc/articles/PMC7909173/ /pubmed/33663135 http://dx.doi.org/10.1097/MD.0000000000024955 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 6800
Xiao, Bohan
Wang, Peiguo
Zhao, Yingru
Liu, Ying
Ye, Zhaoxiang
Using arterial spin labeling blood flow and its histogram analysis to distinguish early-stage nasopharyngeal carcinoma from lymphoid hyperplasia
title Using arterial spin labeling blood flow and its histogram analysis to distinguish early-stage nasopharyngeal carcinoma from lymphoid hyperplasia
title_full Using arterial spin labeling blood flow and its histogram analysis to distinguish early-stage nasopharyngeal carcinoma from lymphoid hyperplasia
title_fullStr Using arterial spin labeling blood flow and its histogram analysis to distinguish early-stage nasopharyngeal carcinoma from lymphoid hyperplasia
title_full_unstemmed Using arterial spin labeling blood flow and its histogram analysis to distinguish early-stage nasopharyngeal carcinoma from lymphoid hyperplasia
title_short Using arterial spin labeling blood flow and its histogram analysis to distinguish early-stage nasopharyngeal carcinoma from lymphoid hyperplasia
title_sort using arterial spin labeling blood flow and its histogram analysis to distinguish early-stage nasopharyngeal carcinoma from lymphoid hyperplasia
topic 6800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909173/
https://www.ncbi.nlm.nih.gov/pubmed/33663135
http://dx.doi.org/10.1097/MD.0000000000024955
work_keys_str_mv AT xiaobohan usingarterialspinlabelingbloodflowanditshistogramanalysistodistinguishearlystagenasopharyngealcarcinomafromlymphoidhyperplasia
AT wangpeiguo usingarterialspinlabelingbloodflowanditshistogramanalysistodistinguishearlystagenasopharyngealcarcinomafromlymphoidhyperplasia
AT zhaoyingru usingarterialspinlabelingbloodflowanditshistogramanalysistodistinguishearlystagenasopharyngealcarcinomafromlymphoidhyperplasia
AT liuying usingarterialspinlabelingbloodflowanditshistogramanalysistodistinguishearlystagenasopharyngealcarcinomafromlymphoidhyperplasia
AT yezhaoxiang usingarterialspinlabelingbloodflowanditshistogramanalysistodistinguishearlystagenasopharyngealcarcinomafromlymphoidhyperplasia