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Novel oxidative stress-related prognostic biomarkers for melanoma associated with tumor metastasis

Skin cutaneous melanoma (SKCM) is a prevalent skin cancer whose metastatic form is dangerous due to its high morbidity and mortality. Previous studies have systematically established the vital role of oxidative stress (OS) in melanoma progression. This study aimed to identify prognostic OS genes clo...

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Autores principales: Wu, Xianpei, Zhao, Jinmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909214/
https://www.ncbi.nlm.nih.gov/pubmed/33663112
http://dx.doi.org/10.1097/MD.0000000000024866
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author Wu, Xianpei
Zhao, Jinmin
author_facet Wu, Xianpei
Zhao, Jinmin
author_sort Wu, Xianpei
collection PubMed
description Skin cutaneous melanoma (SKCM) is a prevalent skin cancer whose metastatic form is dangerous due to its high morbidity and mortality. Previous studies have systematically established the vital role of oxidative stress (OS) in melanoma progression. This study aimed to identify prognostic OS genes closely associated with SKCM and illustrate their potential mechanisms. Transcriptome data and corresponding clinical traits of patients with SKCM were retrieved from The Cancer Genome Atlas and Gene Expression Omnibus databases. A weighted gene co-expression network analysis was conducted to identify relationships between clinical features and OS genes in specific modules. Subsequently, Cox regression analysis was performed on candidate OS genes; four hub prognosis-associated OS genes (AKAP9, VPS13C, ACSL4, and HMOX2) were identified to construct a prognostic model. After a series of bioinformatics analysis, our prognostic model was identified significantly associated with the overall survival of patients with SKCM and metastatic ability of the cancer. Furthermore, our risk model demonstrated improved diagnostic accuracy in the Cancer Genome Atlas and Gene Expression Omnibus cohorts. In addition, we established 2 nomograms based on either risk score or hub genes, which displayed favorable discriminating ability for SKCM. Our results provide novel insight into the potential applications of OS-associated genes in SKCM.
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spelling pubmed-79092142021-03-01 Novel oxidative stress-related prognostic biomarkers for melanoma associated with tumor metastasis Wu, Xianpei Zhao, Jinmin Medicine (Baltimore) 5700 Skin cutaneous melanoma (SKCM) is a prevalent skin cancer whose metastatic form is dangerous due to its high morbidity and mortality. Previous studies have systematically established the vital role of oxidative stress (OS) in melanoma progression. This study aimed to identify prognostic OS genes closely associated with SKCM and illustrate their potential mechanisms. Transcriptome data and corresponding clinical traits of patients with SKCM were retrieved from The Cancer Genome Atlas and Gene Expression Omnibus databases. A weighted gene co-expression network analysis was conducted to identify relationships between clinical features and OS genes in specific modules. Subsequently, Cox regression analysis was performed on candidate OS genes; four hub prognosis-associated OS genes (AKAP9, VPS13C, ACSL4, and HMOX2) were identified to construct a prognostic model. After a series of bioinformatics analysis, our prognostic model was identified significantly associated with the overall survival of patients with SKCM and metastatic ability of the cancer. Furthermore, our risk model demonstrated improved diagnostic accuracy in the Cancer Genome Atlas and Gene Expression Omnibus cohorts. In addition, we established 2 nomograms based on either risk score or hub genes, which displayed favorable discriminating ability for SKCM. Our results provide novel insight into the potential applications of OS-associated genes in SKCM. Lippincott Williams & Wilkins 2021-02-26 /pmc/articles/PMC7909214/ /pubmed/33663112 http://dx.doi.org/10.1097/MD.0000000000024866 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5700
Wu, Xianpei
Zhao, Jinmin
Novel oxidative stress-related prognostic biomarkers for melanoma associated with tumor metastasis
title Novel oxidative stress-related prognostic biomarkers for melanoma associated with tumor metastasis
title_full Novel oxidative stress-related prognostic biomarkers for melanoma associated with tumor metastasis
title_fullStr Novel oxidative stress-related prognostic biomarkers for melanoma associated with tumor metastasis
title_full_unstemmed Novel oxidative stress-related prognostic biomarkers for melanoma associated with tumor metastasis
title_short Novel oxidative stress-related prognostic biomarkers for melanoma associated with tumor metastasis
title_sort novel oxidative stress-related prognostic biomarkers for melanoma associated with tumor metastasis
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909214/
https://www.ncbi.nlm.nih.gov/pubmed/33663112
http://dx.doi.org/10.1097/MD.0000000000024866
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