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Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia

“Functional communication” refers to an individual’s ability to communicate effectively in his or her everyday environment, and thus is a paramount skill to monitor and target therapeutically in people with aphasia. However, traditional controlled-paradigm assessments commonly used in both research...

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Autores principales: Gallée, Jeanne, Cordella, Claire, Fedorenko, Evelina, Hochberg, Daisy, Touroutoglou, Alexandra, Quimby, Megan, Dickerson, Bradford C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909266/
https://www.ncbi.nlm.nih.gov/pubmed/33498260
http://dx.doi.org/10.3390/brainsci11020130
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author Gallée, Jeanne
Cordella, Claire
Fedorenko, Evelina
Hochberg, Daisy
Touroutoglou, Alexandra
Quimby, Megan
Dickerson, Bradford C.
author_facet Gallée, Jeanne
Cordella, Claire
Fedorenko, Evelina
Hochberg, Daisy
Touroutoglou, Alexandra
Quimby, Megan
Dickerson, Bradford C.
author_sort Gallée, Jeanne
collection PubMed
description “Functional communication” refers to an individual’s ability to communicate effectively in his or her everyday environment, and thus is a paramount skill to monitor and target therapeutically in people with aphasia. However, traditional controlled-paradigm assessments commonly used in both research and clinical settings often fail to adequately capture this ability. In the current study, facets of functional communication were measured from picture-elicited speech samples from 70 individuals with mild primary progressive aphasia (PPA), including the three variants, and 31 age-matched controls. Building upon methods recently used by Berube et al. (2019), we measured the informativeness of speech by quantifying the content of each patient’s description that was relevant to a picture relative to the total amount of speech they produced. Importantly, form-based errors, such as mispronunciations of words, unusual word choices, or grammatical mistakes are not penalized in this approach. We found that the relative informativeness, or efficiency, of speech was preserved in non-fluent variant PPA patients as compared with controls, whereas the logopenic and semantic variant PPA patients produced significantly less informative output. Furthermore, reduced informativeness in the semantic variant is attributable to a lower production of content units and a propensity for self-referential tangents, whereas for the logopenic variant, a lower production of content units and relatively ”empty” speech and false starts contribute to this reduction. These findings demonstrate that functional communication impairment does not uniformly affect all the PPA variants and highlight the utility of naturalistic speech analysis for measuring the breakdown of functional communication in PPA.
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spelling pubmed-79092662021-02-27 Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia Gallée, Jeanne Cordella, Claire Fedorenko, Evelina Hochberg, Daisy Touroutoglou, Alexandra Quimby, Megan Dickerson, Bradford C. Brain Sci Article “Functional communication” refers to an individual’s ability to communicate effectively in his or her everyday environment, and thus is a paramount skill to monitor and target therapeutically in people with aphasia. However, traditional controlled-paradigm assessments commonly used in both research and clinical settings often fail to adequately capture this ability. In the current study, facets of functional communication were measured from picture-elicited speech samples from 70 individuals with mild primary progressive aphasia (PPA), including the three variants, and 31 age-matched controls. Building upon methods recently used by Berube et al. (2019), we measured the informativeness of speech by quantifying the content of each patient’s description that was relevant to a picture relative to the total amount of speech they produced. Importantly, form-based errors, such as mispronunciations of words, unusual word choices, or grammatical mistakes are not penalized in this approach. We found that the relative informativeness, or efficiency, of speech was preserved in non-fluent variant PPA patients as compared with controls, whereas the logopenic and semantic variant PPA patients produced significantly less informative output. Furthermore, reduced informativeness in the semantic variant is attributable to a lower production of content units and a propensity for self-referential tangents, whereas for the logopenic variant, a lower production of content units and relatively ”empty” speech and false starts contribute to this reduction. These findings demonstrate that functional communication impairment does not uniformly affect all the PPA variants and highlight the utility of naturalistic speech analysis for measuring the breakdown of functional communication in PPA. MDPI 2021-01-20 /pmc/articles/PMC7909266/ /pubmed/33498260 http://dx.doi.org/10.3390/brainsci11020130 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gallée, Jeanne
Cordella, Claire
Fedorenko, Evelina
Hochberg, Daisy
Touroutoglou, Alexandra
Quimby, Megan
Dickerson, Bradford C.
Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
title Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
title_full Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
title_fullStr Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
title_full_unstemmed Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
title_short Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
title_sort breakdowns in informativeness of naturalistic speech production in primary progressive aphasia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909266/
https://www.ncbi.nlm.nih.gov/pubmed/33498260
http://dx.doi.org/10.3390/brainsci11020130
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