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Natural and Artificial Mechanisms of Mitochondrial Genome Elimination

The generally accepted theory of the genetic drift of mitochondrial alleles during mammalian ontogenesis is based on the presence of a selective bottleneck in the female germline. However, there is a variety of different theories on the pathways of genetic regulation of mitochondrial DNA (mtDNA) dyn...

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Autores principales: Zakirova, Elvira G., Muzyka, Vladimir V., Mazunin, Ilya O., Orishchenko, Konstantin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909434/
https://www.ncbi.nlm.nih.gov/pubmed/33498399
http://dx.doi.org/10.3390/life11020076
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author Zakirova, Elvira G.
Muzyka, Vladimir V.
Mazunin, Ilya O.
Orishchenko, Konstantin E.
author_facet Zakirova, Elvira G.
Muzyka, Vladimir V.
Mazunin, Ilya O.
Orishchenko, Konstantin E.
author_sort Zakirova, Elvira G.
collection PubMed
description The generally accepted theory of the genetic drift of mitochondrial alleles during mammalian ontogenesis is based on the presence of a selective bottleneck in the female germline. However, there is a variety of different theories on the pathways of genetic regulation of mitochondrial DNA (mtDNA) dynamics in oogenesis and adult somatic cells. The current review summarizes present knowledge on the natural mechanisms of mitochondrial genome elimination during mammalian development. We also discuss the variety of existing and developing methodologies for artificial manipulation of the mtDNA heteroplasmy level. Understanding of the basics of mtDNA dynamics will shed the light on the pathogenesis and potential therapies of human diseases associated with mitochondrial dysfunction.
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spelling pubmed-79094342021-02-27 Natural and Artificial Mechanisms of Mitochondrial Genome Elimination Zakirova, Elvira G. Muzyka, Vladimir V. Mazunin, Ilya O. Orishchenko, Konstantin E. Life (Basel) Review The generally accepted theory of the genetic drift of mitochondrial alleles during mammalian ontogenesis is based on the presence of a selective bottleneck in the female germline. However, there is a variety of different theories on the pathways of genetic regulation of mitochondrial DNA (mtDNA) dynamics in oogenesis and adult somatic cells. The current review summarizes present knowledge on the natural mechanisms of mitochondrial genome elimination during mammalian development. We also discuss the variety of existing and developing methodologies for artificial manipulation of the mtDNA heteroplasmy level. Understanding of the basics of mtDNA dynamics will shed the light on the pathogenesis and potential therapies of human diseases associated with mitochondrial dysfunction. MDPI 2021-01-20 /pmc/articles/PMC7909434/ /pubmed/33498399 http://dx.doi.org/10.3390/life11020076 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zakirova, Elvira G.
Muzyka, Vladimir V.
Mazunin, Ilya O.
Orishchenko, Konstantin E.
Natural and Artificial Mechanisms of Mitochondrial Genome Elimination
title Natural and Artificial Mechanisms of Mitochondrial Genome Elimination
title_full Natural and Artificial Mechanisms of Mitochondrial Genome Elimination
title_fullStr Natural and Artificial Mechanisms of Mitochondrial Genome Elimination
title_full_unstemmed Natural and Artificial Mechanisms of Mitochondrial Genome Elimination
title_short Natural and Artificial Mechanisms of Mitochondrial Genome Elimination
title_sort natural and artificial mechanisms of mitochondrial genome elimination
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909434/
https://www.ncbi.nlm.nih.gov/pubmed/33498399
http://dx.doi.org/10.3390/life11020076
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