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Assessment of Inorganic Phosphate Intake by the Measurement of the Phosphate/Urea Nitrogen Ratio in Urine

In chronic kidney disease (CKD) patients, it would be desirable to reduce the intake of inorganic phosphate (P) rather than limit the intake of P contained in proteins. Urinary excretion of P should reflect intestinal absorption of P(inorganic plus protein-derived). The aim of the present study is t...

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Autores principales: Pendón-Ruiz de Mier, María Victoria, Vergara, Noemí, Rodelo-Haad, Cristian, López-Zamorano, María Dolores, Membrives-González, Cristina, López-Baltanás, Rodrigo, Muñoz-Castañeda, Juan Rafael, Caravaca, Francisco, Martín-Malo, Alejandro, Felsenfeld, Arnold J., De la Torre, Eugenio J., Soriano, Sagrario, Santamaría, Rafael, Rodríguez, Mariano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909516/
https://www.ncbi.nlm.nih.gov/pubmed/33498560
http://dx.doi.org/10.3390/nu13020292
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author Pendón-Ruiz de Mier, María Victoria
Vergara, Noemí
Rodelo-Haad, Cristian
López-Zamorano, María Dolores
Membrives-González, Cristina
López-Baltanás, Rodrigo
Muñoz-Castañeda, Juan Rafael
Caravaca, Francisco
Martín-Malo, Alejandro
Felsenfeld, Arnold J.
De la Torre, Eugenio J.
Soriano, Sagrario
Santamaría, Rafael
Rodríguez, Mariano
author_facet Pendón-Ruiz de Mier, María Victoria
Vergara, Noemí
Rodelo-Haad, Cristian
López-Zamorano, María Dolores
Membrives-González, Cristina
López-Baltanás, Rodrigo
Muñoz-Castañeda, Juan Rafael
Caravaca, Francisco
Martín-Malo, Alejandro
Felsenfeld, Arnold J.
De la Torre, Eugenio J.
Soriano, Sagrario
Santamaría, Rafael
Rodríguez, Mariano
author_sort Pendón-Ruiz de Mier, María Victoria
collection PubMed
description In chronic kidney disease (CKD) patients, it would be desirable to reduce the intake of inorganic phosphate (P) rather than limit the intake of P contained in proteins. Urinary excretion of P should reflect intestinal absorption of P(inorganic plus protein-derived). The aim of the present study is to determine whether the ratio of urinary P to urinary urea nitrogen (P/UUN ratio) helps identify patients with a high intake of inorganic P.A cross-sectional study was performed in 71 patients affected by metabolic syndrome with CKD (stages 2–3) with normal serum P concentration. A 3-day dietary survey was performed to estimate the average daily amount and the source of P ingested. The daily intake of P was 1086.5 ± 361.3 mg/day; 64% contained in animal proteins, 22% in vegetable proteins, and 14% as inorganic P. The total amount of P ingested did not correlate with daily phosphaturia, but it did correlate with the P/UUN ratio (p < 0.018). Patients with the highest tertile of the P/UUN ratio >71.1 mg/g presented more abundant inorganic P intake (p < 0.038).The P/UUN ratio is suggested to be a marker of inorganic P intake. This finding might be useful in clinical practices to identify the source of dietary P and to make personalized dietary recommendations directed to reduce inorganic P intake.
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spelling pubmed-79095162021-02-27 Assessment of Inorganic Phosphate Intake by the Measurement of the Phosphate/Urea Nitrogen Ratio in Urine Pendón-Ruiz de Mier, María Victoria Vergara, Noemí Rodelo-Haad, Cristian López-Zamorano, María Dolores Membrives-González, Cristina López-Baltanás, Rodrigo Muñoz-Castañeda, Juan Rafael Caravaca, Francisco Martín-Malo, Alejandro Felsenfeld, Arnold J. De la Torre, Eugenio J. Soriano, Sagrario Santamaría, Rafael Rodríguez, Mariano Nutrients Article In chronic kidney disease (CKD) patients, it would be desirable to reduce the intake of inorganic phosphate (P) rather than limit the intake of P contained in proteins. Urinary excretion of P should reflect intestinal absorption of P(inorganic plus protein-derived). The aim of the present study is to determine whether the ratio of urinary P to urinary urea nitrogen (P/UUN ratio) helps identify patients with a high intake of inorganic P.A cross-sectional study was performed in 71 patients affected by metabolic syndrome with CKD (stages 2–3) with normal serum P concentration. A 3-day dietary survey was performed to estimate the average daily amount and the source of P ingested. The daily intake of P was 1086.5 ± 361.3 mg/day; 64% contained in animal proteins, 22% in vegetable proteins, and 14% as inorganic P. The total amount of P ingested did not correlate with daily phosphaturia, but it did correlate with the P/UUN ratio (p < 0.018). Patients with the highest tertile of the P/UUN ratio >71.1 mg/g presented more abundant inorganic P intake (p < 0.038).The P/UUN ratio is suggested to be a marker of inorganic P intake. This finding might be useful in clinical practices to identify the source of dietary P and to make personalized dietary recommendations directed to reduce inorganic P intake. MDPI 2021-01-20 /pmc/articles/PMC7909516/ /pubmed/33498560 http://dx.doi.org/10.3390/nu13020292 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pendón-Ruiz de Mier, María Victoria
Vergara, Noemí
Rodelo-Haad, Cristian
López-Zamorano, María Dolores
Membrives-González, Cristina
López-Baltanás, Rodrigo
Muñoz-Castañeda, Juan Rafael
Caravaca, Francisco
Martín-Malo, Alejandro
Felsenfeld, Arnold J.
De la Torre, Eugenio J.
Soriano, Sagrario
Santamaría, Rafael
Rodríguez, Mariano
Assessment of Inorganic Phosphate Intake by the Measurement of the Phosphate/Urea Nitrogen Ratio in Urine
title Assessment of Inorganic Phosphate Intake by the Measurement of the Phosphate/Urea Nitrogen Ratio in Urine
title_full Assessment of Inorganic Phosphate Intake by the Measurement of the Phosphate/Urea Nitrogen Ratio in Urine
title_fullStr Assessment of Inorganic Phosphate Intake by the Measurement of the Phosphate/Urea Nitrogen Ratio in Urine
title_full_unstemmed Assessment of Inorganic Phosphate Intake by the Measurement of the Phosphate/Urea Nitrogen Ratio in Urine
title_short Assessment of Inorganic Phosphate Intake by the Measurement of the Phosphate/Urea Nitrogen Ratio in Urine
title_sort assessment of inorganic phosphate intake by the measurement of the phosphate/urea nitrogen ratio in urine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909516/
https://www.ncbi.nlm.nih.gov/pubmed/33498560
http://dx.doi.org/10.3390/nu13020292
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