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Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers
Triple-negative breast cancer (TNBC) is a group of breast cancers which neither express hormonal receptors nor human epidermal growth factor receptor. Hence, there is a lack of currently known targeted therapies and the only available line of systemic treatment option is chemotherapy or more recentl...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909869/ https://www.ncbi.nlm.nih.gov/pubmed/33543229 http://dx.doi.org/10.1042/BSR20204092 |
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author | Abd El-Aziz, Yomna S. Spillane, Andrew J. Jansson, Patric J. Sahni, Sumit |
author_facet | Abd El-Aziz, Yomna S. Spillane, Andrew J. Jansson, Patric J. Sahni, Sumit |
author_sort | Abd El-Aziz, Yomna S. |
collection | PubMed |
description | Triple-negative breast cancer (TNBC) is a group of breast cancers which neither express hormonal receptors nor human epidermal growth factor receptor. Hence, there is a lack of currently known targeted therapies and the only available line of systemic treatment option is chemotherapy or more recently immune therapy. However, in patients with relapsed disease after adjuvant or neoadjuvant therapy, resistance to chemotherapeutic agents has often developed, which results in poor treatment response. Multidrug resistance (MDR) has emerged as an important mechanism by which TNBCs mediate drug resistance and occurs primarily due to overexpression of ATP-binding cassette (ABC) transporter proteins such as P-glycoprotein (Pgp). Pgp overexpression had been linked to poor outcome, reduced survival rates and chemoresistance in patients. The aim of this mini-review is to provide a topical overview of the recent studies and to generate further interest in this critical research area, with the aim to develop an effective and safe approach for overcoming Pgp-mediated chemoresistance in TNBC. |
format | Online Article Text |
id | pubmed-7909869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79098692021-03-04 Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers Abd El-Aziz, Yomna S. Spillane, Andrew J. Jansson, Patric J. Sahni, Sumit Biosci Rep Cancer Triple-negative breast cancer (TNBC) is a group of breast cancers which neither express hormonal receptors nor human epidermal growth factor receptor. Hence, there is a lack of currently known targeted therapies and the only available line of systemic treatment option is chemotherapy or more recently immune therapy. However, in patients with relapsed disease after adjuvant or neoadjuvant therapy, resistance to chemotherapeutic agents has often developed, which results in poor treatment response. Multidrug resistance (MDR) has emerged as an important mechanism by which TNBCs mediate drug resistance and occurs primarily due to overexpression of ATP-binding cassette (ABC) transporter proteins such as P-glycoprotein (Pgp). Pgp overexpression had been linked to poor outcome, reduced survival rates and chemoresistance in patients. The aim of this mini-review is to provide a topical overview of the recent studies and to generate further interest in this critical research area, with the aim to develop an effective and safe approach for overcoming Pgp-mediated chemoresistance in TNBC. Portland Press Ltd. 2021-02-17 /pmc/articles/PMC7909869/ /pubmed/33543229 http://dx.doi.org/10.1042/BSR20204092 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Cancer Abd El-Aziz, Yomna S. Spillane, Andrew J. Jansson, Patric J. Sahni, Sumit Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers |
title | Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers |
title_full | Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers |
title_fullStr | Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers |
title_full_unstemmed | Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers |
title_short | Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers |
title_sort | role of abcb1 in mediating chemoresistance of triple-negative breast cancers |
topic | Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909869/ https://www.ncbi.nlm.nih.gov/pubmed/33543229 http://dx.doi.org/10.1042/BSR20204092 |
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