Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance

The importance of hypothalamic insulin signaling on feeding and glucose metabolism remains unclear. We report that insulin acts on AgRP neurons to acutely decrease meal size and thereby limit postprandial glucose and insulin excursions. The promotion of insulin signaling in AgRP neurons decreased me...

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Detalles Bibliográficos
Autores principales: Dodd, Garron T., Kim, Seung Jae, Méquinion, Mathieu, Xirouchaki, Chrysovalantou E., Brüning, Jens C., Andrews, Zane B., Tiganis, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909880/
https://www.ncbi.nlm.nih.gov/pubmed/33637536
http://dx.doi.org/10.1126/sciadv.abf4100

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