Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer

CD4 T cells have been implicated in cancer immunity for their helper functions. Moreover, their direct cytotoxic potential has been shown in some patients with cancer. Here, by mining single-cell RNA-seq datasets, we identified CD4 T cell clusters displaying cytotoxic phenotypes in different human c...

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Detalles Bibliográficos
Autores principales: Cachot, Amélie, Bilous, Mariia, Liu, Yen-Cheng, Li, Xiaokang, Saillard, Margaux, Cenerenti, Mara, Rockinger, Georg Alexander, Wyss, Tania, Guillaume, Philippe, Schmidt, Julien, Genolet, Raphaël, Ercolano, Giuseppe, Protti, Maria Pia, Reith, Walter, Ioannidou, Kalliopi, de Leval, Laurence, Trapani, Joseph A., Coukos, George, Harari, Alexandre, Speiser, Daniel E., Mathis, Alexander, Gfeller, David, Altug, Hatice, Romero, Pedro, Jandus, Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909889/
https://www.ncbi.nlm.nih.gov/pubmed/33637530
http://dx.doi.org/10.1126/sciadv.abe3348

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