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Title of article: Mucosal-associated invariant T cells in lung diseases

The lungs are directly connected to the external environment, which makes them more vulnerable to infection and injury. They are protected by the respiratory epithelium and immune cells to maintain a dynamic balance. Both innate and adaptive immune cells are involved in the pathogenesis of lung dise...

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Autores principales: Wen, Xue, Zhang, Xingli, Nian, Siji, Wei, Gang, Guo, Xiyuan, Yu, Hong, Xie, Xiang, Ye, Yingchun, Yuan, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909906/
https://www.ncbi.nlm.nih.gov/pubmed/33647824
http://dx.doi.org/10.1016/j.intimp.2021.107485
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author Wen, Xue
Zhang, Xingli
Nian, Siji
Wei, Gang
Guo, Xiyuan
Yu, Hong
Xie, Xiang
Ye, Yingchun
Yuan, Qing
author_facet Wen, Xue
Zhang, Xingli
Nian, Siji
Wei, Gang
Guo, Xiyuan
Yu, Hong
Xie, Xiang
Ye, Yingchun
Yuan, Qing
author_sort Wen, Xue
collection PubMed
description The lungs are directly connected to the external environment, which makes them more vulnerable to infection and injury. They are protected by the respiratory epithelium and immune cells to maintain a dynamic balance. Both innate and adaptive immune cells are involved in the pathogenesis of lung diseases. Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells, which have attracted increasing attention in recent years. Although MAIT cells account for a small part of the total immune cells in the lungs, evidence suggests that these cells are activated by T cell receptors and/or cytokine receptors and mediate immune response. They play an important role in immunosurveillance and immunity against microbial infection, and recent studies have shown that subsets of MAIT cells play a role in promoting pulmonary inflammation. Emerging data indicate that MAIT cells are involved in the immune response against SARS-CoV-2 and possible immunopathogenesis in COVID-19. Here, we introduce MAIT cell biology to clarify their role in the immune response. Then we review MAIT cells in human and murine lung diseases, including asthma, chronic obstructive pulmonary disease, pneumonia, pulmonary tuberculosis and lung cancer, and discuss their possible protective and pathological effects. MAIT cells represent an attractive marker and potential therapeutic target for disease progression, thus providing new strategies for the treatment of lung diseases.
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spelling pubmed-79099062021-03-01 Title of article: Mucosal-associated invariant T cells in lung diseases Wen, Xue Zhang, Xingli Nian, Siji Wei, Gang Guo, Xiyuan Yu, Hong Xie, Xiang Ye, Yingchun Yuan, Qing Int Immunopharmacol Review The lungs are directly connected to the external environment, which makes them more vulnerable to infection and injury. They are protected by the respiratory epithelium and immune cells to maintain a dynamic balance. Both innate and adaptive immune cells are involved in the pathogenesis of lung diseases. Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells, which have attracted increasing attention in recent years. Although MAIT cells account for a small part of the total immune cells in the lungs, evidence suggests that these cells are activated by T cell receptors and/or cytokine receptors and mediate immune response. They play an important role in immunosurveillance and immunity against microbial infection, and recent studies have shown that subsets of MAIT cells play a role in promoting pulmonary inflammation. Emerging data indicate that MAIT cells are involved in the immune response against SARS-CoV-2 and possible immunopathogenesis in COVID-19. Here, we introduce MAIT cell biology to clarify their role in the immune response. Then we review MAIT cells in human and murine lung diseases, including asthma, chronic obstructive pulmonary disease, pneumonia, pulmonary tuberculosis and lung cancer, and discuss their possible protective and pathological effects. MAIT cells represent an attractive marker and potential therapeutic target for disease progression, thus providing new strategies for the treatment of lung diseases. Elsevier B.V. 2021-05 2021-02-26 /pmc/articles/PMC7909906/ /pubmed/33647824 http://dx.doi.org/10.1016/j.intimp.2021.107485 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Wen, Xue
Zhang, Xingli
Nian, Siji
Wei, Gang
Guo, Xiyuan
Yu, Hong
Xie, Xiang
Ye, Yingchun
Yuan, Qing
Title of article: Mucosal-associated invariant T cells in lung diseases
title Title of article: Mucosal-associated invariant T cells in lung diseases
title_full Title of article: Mucosal-associated invariant T cells in lung diseases
title_fullStr Title of article: Mucosal-associated invariant T cells in lung diseases
title_full_unstemmed Title of article: Mucosal-associated invariant T cells in lung diseases
title_short Title of article: Mucosal-associated invariant T cells in lung diseases
title_sort title of article: mucosal-associated invariant t cells in lung diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909906/
https://www.ncbi.nlm.nih.gov/pubmed/33647824
http://dx.doi.org/10.1016/j.intimp.2021.107485
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