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Light-emitting diode stimulates radiodermatitis recovery

PURPOSE: To evaluate the effect of light-emitting diode (LED) in an experimental model of radiodermatitis. METHODS: Ten male Wistar rats weighing 200–250 g were analyzed. Radiation was delivered in a single dose (20 Gy with Strontium-90 dermatological plaques), two areas per animal. After 15 days, t...

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Autores principales: Camargo, Cristina Pires, Carvalho, Heloisa Andrade, Maluf, Feres Camargo, Sousa, Alexandre Agostinho da Cruz, Perin, Paulo Otavio Maluf, Perin, Marcela Maluf, Morais-Besteiro, Julio, Gemperli, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909943/
https://www.ncbi.nlm.nih.gov/pubmed/33656099
http://dx.doi.org/10.1590/ACB360301
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author Camargo, Cristina Pires
Carvalho, Heloisa Andrade
Maluf, Feres Camargo
Sousa, Alexandre Agostinho da Cruz
Perin, Paulo Otavio Maluf
Perin, Marcela Maluf
Morais-Besteiro, Julio
Gemperli, Rolf
author_facet Camargo, Cristina Pires
Carvalho, Heloisa Andrade
Maluf, Feres Camargo
Sousa, Alexandre Agostinho da Cruz
Perin, Paulo Otavio Maluf
Perin, Marcela Maluf
Morais-Besteiro, Julio
Gemperli, Rolf
author_sort Camargo, Cristina Pires
collection PubMed
description PURPOSE: To evaluate the effect of light-emitting diode (LED) in an experimental model of radiodermatitis. METHODS: Ten male Wistar rats weighing 200–250 g were analyzed. Radiation was delivered in a single dose (20 Gy with Strontium-90 dermatological plaques), two areas per animal. After 15 days, they were divided into two groups: control group (n = 5) and LED group (n = 5), which was treated during 21 days later (LED 660 nm, 10 min in alternate days). The endpoints were radiodermatitis scale, histological analysis HE, Picrius Sirius and the gene expression of interleukin-10 (IL-10) and matrix metalloproteinase-9 (MMP-9). RESULTS: The LED group showed a higher number of dermal appendages (p = 0.04) and angiogenesis(p = 0.007), a tendency towards higher IL-10 (p = 0.06) and an increase in MMP-9 (p = 0.004) when compared to the control group. CONCLUSIONS: This study suggested that the use of LED for radiodermatitis increased skin regeneration.
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spelling pubmed-79099432021-03-10 Light-emitting diode stimulates radiodermatitis recovery Camargo, Cristina Pires Carvalho, Heloisa Andrade Maluf, Feres Camargo Sousa, Alexandre Agostinho da Cruz Perin, Paulo Otavio Maluf Perin, Marcela Maluf Morais-Besteiro, Julio Gemperli, Rolf Acta Cir Bras Original Article PURPOSE: To evaluate the effect of light-emitting diode (LED) in an experimental model of radiodermatitis. METHODS: Ten male Wistar rats weighing 200–250 g were analyzed. Radiation was delivered in a single dose (20 Gy with Strontium-90 dermatological plaques), two areas per animal. After 15 days, they were divided into two groups: control group (n = 5) and LED group (n = 5), which was treated during 21 days later (LED 660 nm, 10 min in alternate days). The endpoints were radiodermatitis scale, histological analysis HE, Picrius Sirius and the gene expression of interleukin-10 (IL-10) and matrix metalloproteinase-9 (MMP-9). RESULTS: The LED group showed a higher number of dermal appendages (p = 0.04) and angiogenesis(p = 0.007), a tendency towards higher IL-10 (p = 0.06) and an increase in MMP-9 (p = 0.004) when compared to the control group. CONCLUSIONS: This study suggested that the use of LED for radiodermatitis increased skin regeneration. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2021-02-26 /pmc/articles/PMC7909943/ /pubmed/33656099 http://dx.doi.org/10.1590/ACB360301 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Camargo, Cristina Pires
Carvalho, Heloisa Andrade
Maluf, Feres Camargo
Sousa, Alexandre Agostinho da Cruz
Perin, Paulo Otavio Maluf
Perin, Marcela Maluf
Morais-Besteiro, Julio
Gemperli, Rolf
Light-emitting diode stimulates radiodermatitis recovery
title Light-emitting diode stimulates radiodermatitis recovery
title_full Light-emitting diode stimulates radiodermatitis recovery
title_fullStr Light-emitting diode stimulates radiodermatitis recovery
title_full_unstemmed Light-emitting diode stimulates radiodermatitis recovery
title_short Light-emitting diode stimulates radiodermatitis recovery
title_sort light-emitting diode stimulates radiodermatitis recovery
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909943/
https://www.ncbi.nlm.nih.gov/pubmed/33656099
http://dx.doi.org/10.1590/ACB360301
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