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Light-emitting diode stimulates radiodermatitis recovery
PURPOSE: To evaluate the effect of light-emitting diode (LED) in an experimental model of radiodermatitis. METHODS: Ten male Wistar rats weighing 200–250 g were analyzed. Radiation was delivered in a single dose (20 Gy with Strontium-90 dermatological plaques), two areas per animal. After 15 days, t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909943/ https://www.ncbi.nlm.nih.gov/pubmed/33656099 http://dx.doi.org/10.1590/ACB360301 |
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author | Camargo, Cristina Pires Carvalho, Heloisa Andrade Maluf, Feres Camargo Sousa, Alexandre Agostinho da Cruz Perin, Paulo Otavio Maluf Perin, Marcela Maluf Morais-Besteiro, Julio Gemperli, Rolf |
author_facet | Camargo, Cristina Pires Carvalho, Heloisa Andrade Maluf, Feres Camargo Sousa, Alexandre Agostinho da Cruz Perin, Paulo Otavio Maluf Perin, Marcela Maluf Morais-Besteiro, Julio Gemperli, Rolf |
author_sort | Camargo, Cristina Pires |
collection | PubMed |
description | PURPOSE: To evaluate the effect of light-emitting diode (LED) in an experimental model of radiodermatitis. METHODS: Ten male Wistar rats weighing 200–250 g were analyzed. Radiation was delivered in a single dose (20 Gy with Strontium-90 dermatological plaques), two areas per animal. After 15 days, they were divided into two groups: control group (n = 5) and LED group (n = 5), which was treated during 21 days later (LED 660 nm, 10 min in alternate days). The endpoints were radiodermatitis scale, histological analysis HE, Picrius Sirius and the gene expression of interleukin-10 (IL-10) and matrix metalloproteinase-9 (MMP-9). RESULTS: The LED group showed a higher number of dermal appendages (p = 0.04) and angiogenesis(p = 0.007), a tendency towards higher IL-10 (p = 0.06) and an increase in MMP-9 (p = 0.004) when compared to the control group. CONCLUSIONS: This study suggested that the use of LED for radiodermatitis increased skin regeneration. |
format | Online Article Text |
id | pubmed-7909943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
record_format | MEDLINE/PubMed |
spelling | pubmed-79099432021-03-10 Light-emitting diode stimulates radiodermatitis recovery Camargo, Cristina Pires Carvalho, Heloisa Andrade Maluf, Feres Camargo Sousa, Alexandre Agostinho da Cruz Perin, Paulo Otavio Maluf Perin, Marcela Maluf Morais-Besteiro, Julio Gemperli, Rolf Acta Cir Bras Original Article PURPOSE: To evaluate the effect of light-emitting diode (LED) in an experimental model of radiodermatitis. METHODS: Ten male Wistar rats weighing 200–250 g were analyzed. Radiation was delivered in a single dose (20 Gy with Strontium-90 dermatological plaques), two areas per animal. After 15 days, they were divided into two groups: control group (n = 5) and LED group (n = 5), which was treated during 21 days later (LED 660 nm, 10 min in alternate days). The endpoints were radiodermatitis scale, histological analysis HE, Picrius Sirius and the gene expression of interleukin-10 (IL-10) and matrix metalloproteinase-9 (MMP-9). RESULTS: The LED group showed a higher number of dermal appendages (p = 0.04) and angiogenesis(p = 0.007), a tendency towards higher IL-10 (p = 0.06) and an increase in MMP-9 (p = 0.004) when compared to the control group. CONCLUSIONS: This study suggested that the use of LED for radiodermatitis increased skin regeneration. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2021-02-26 /pmc/articles/PMC7909943/ /pubmed/33656099 http://dx.doi.org/10.1590/ACB360301 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Camargo, Cristina Pires Carvalho, Heloisa Andrade Maluf, Feres Camargo Sousa, Alexandre Agostinho da Cruz Perin, Paulo Otavio Maluf Perin, Marcela Maluf Morais-Besteiro, Julio Gemperli, Rolf Light-emitting diode stimulates radiodermatitis recovery |
title | Light-emitting diode stimulates radiodermatitis recovery |
title_full | Light-emitting diode stimulates radiodermatitis recovery |
title_fullStr | Light-emitting diode stimulates radiodermatitis recovery |
title_full_unstemmed | Light-emitting diode stimulates radiodermatitis recovery |
title_short | Light-emitting diode stimulates radiodermatitis recovery |
title_sort | light-emitting diode stimulates radiodermatitis recovery |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909943/ https://www.ncbi.nlm.nih.gov/pubmed/33656099 http://dx.doi.org/10.1590/ACB360301 |
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