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Factors associated with a prolonged negative conversion of viral RNA in patients with COVID-19

OBJECTIVES: The aim of this study was to identify the factors influencing the delay in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA negative conversion. METHODS: A cohort study was conducted that included patients with coronavirus disease 2019 (COVID-19) admitted to the Tunisian...

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Autores principales: Bennasrallah, Cyrine, Zemni, Imen, Dhouib, Wafa, Sriha, Haythem, Mezhoud, Nourhene, Bouslama, Samar, Taboubi, Wael, Beji, Meriem Oumaima, Kacem, Meriem, Abroug, Hela, Fredj, Manel Ben, Loussaief, Chawki, Belguith, Asma Sriha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910140/
https://www.ncbi.nlm.nih.gov/pubmed/33647508
http://dx.doi.org/10.1016/j.ijid.2021.02.089
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author Bennasrallah, Cyrine
Zemni, Imen
Dhouib, Wafa
Sriha, Haythem
Mezhoud, Nourhene
Bouslama, Samar
Taboubi, Wael
Beji, Meriem Oumaima
Kacem, Meriem
Abroug, Hela
Fredj, Manel Ben
Loussaief, Chawki
Belguith, Asma Sriha
author_facet Bennasrallah, Cyrine
Zemni, Imen
Dhouib, Wafa
Sriha, Haythem
Mezhoud, Nourhene
Bouslama, Samar
Taboubi, Wael
Beji, Meriem Oumaima
Kacem, Meriem
Abroug, Hela
Fredj, Manel Ben
Loussaief, Chawki
Belguith, Asma Sriha
author_sort Bennasrallah, Cyrine
collection PubMed
description OBJECTIVES: The aim of this study was to identify the factors influencing the delay in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA negative conversion. METHODS: A cohort study was conducted that included patients with coronavirus disease 2019 (COVID-19) admitted to the Tunisian national containment center. Follow-up consisted of a weekly RT-PCR test. Multivariate Cox regression analysis was performed to determine independent predictors associated with negative RNA conversion. RESULTS: Among the 264 patients included, the median duration of viral clearance was 20 days (interquartile range (IQR) 17–32 days). The shortest duration was 9 days and the longest was 58 days. Factors associated with negative conversion of viral RNA were symptoms such as fatigue, fever, and shortness of breath (hazard ratio (HR) 0.600, 95% confidence interval (CI) 0.401–0.897) and face mask use when exposed to COVID-19 cases (HR 2.006, 95% CI 1.247–3.228). The median time to RNA viral conversion was 18 days (IQR 16–21 days) when using masks versus 23 days (IQR 17–36 days) without wearing masks, and 24 days (IQR 18–36 days) for symptomatic patients versus 20 days (IQR 16–30 days) for asymptomatic patients. CONCLUSIONS: The results of this study revealed that during SARS-CoV-2 infection, having symptoms delayed viral clearance, while wearing masks accelerated this conversion. These factors should be taken into consideration for the strategy of isolating infected patients.
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spelling pubmed-79101402021-03-01 Factors associated with a prolonged negative conversion of viral RNA in patients with COVID-19 Bennasrallah, Cyrine Zemni, Imen Dhouib, Wafa Sriha, Haythem Mezhoud, Nourhene Bouslama, Samar Taboubi, Wael Beji, Meriem Oumaima Kacem, Meriem Abroug, Hela Fredj, Manel Ben Loussaief, Chawki Belguith, Asma Sriha Int J Infect Dis Article OBJECTIVES: The aim of this study was to identify the factors influencing the delay in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA negative conversion. METHODS: A cohort study was conducted that included patients with coronavirus disease 2019 (COVID-19) admitted to the Tunisian national containment center. Follow-up consisted of a weekly RT-PCR test. Multivariate Cox regression analysis was performed to determine independent predictors associated with negative RNA conversion. RESULTS: Among the 264 patients included, the median duration of viral clearance was 20 days (interquartile range (IQR) 17–32 days). The shortest duration was 9 days and the longest was 58 days. Factors associated with negative conversion of viral RNA were symptoms such as fatigue, fever, and shortness of breath (hazard ratio (HR) 0.600, 95% confidence interval (CI) 0.401–0.897) and face mask use when exposed to COVID-19 cases (HR 2.006, 95% CI 1.247–3.228). The median time to RNA viral conversion was 18 days (IQR 16–21 days) when using masks versus 23 days (IQR 17–36 days) without wearing masks, and 24 days (IQR 18–36 days) for symptomatic patients versus 20 days (IQR 16–30 days) for asymptomatic patients. CONCLUSIONS: The results of this study revealed that during SARS-CoV-2 infection, having symptoms delayed viral clearance, while wearing masks accelerated this conversion. These factors should be taken into consideration for the strategy of isolating infected patients. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-04 2021-02-27 /pmc/articles/PMC7910140/ /pubmed/33647508 http://dx.doi.org/10.1016/j.ijid.2021.02.089 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Bennasrallah, Cyrine
Zemni, Imen
Dhouib, Wafa
Sriha, Haythem
Mezhoud, Nourhene
Bouslama, Samar
Taboubi, Wael
Beji, Meriem Oumaima
Kacem, Meriem
Abroug, Hela
Fredj, Manel Ben
Loussaief, Chawki
Belguith, Asma Sriha
Factors associated with a prolonged negative conversion of viral RNA in patients with COVID-19
title Factors associated with a prolonged negative conversion of viral RNA in patients with COVID-19
title_full Factors associated with a prolonged negative conversion of viral RNA in patients with COVID-19
title_fullStr Factors associated with a prolonged negative conversion of viral RNA in patients with COVID-19
title_full_unstemmed Factors associated with a prolonged negative conversion of viral RNA in patients with COVID-19
title_short Factors associated with a prolonged negative conversion of viral RNA in patients with COVID-19
title_sort factors associated with a prolonged negative conversion of viral rna in patients with covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910140/
https://www.ncbi.nlm.nih.gov/pubmed/33647508
http://dx.doi.org/10.1016/j.ijid.2021.02.089
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