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Association Analysis Between Catechol-O-Methyltransferase Expression and Cognitive Function in Patients with Schizophrenia, Bipolar Disorder, or Major Depression

INTRODUCTION: Schizophrenia, bipolar disorder (BD), and major depressive disorder are three common mental disorders. Although their diagnosis and treatment differ, they partially overlap. METHODS: To explore the similarities and characteristics of these three psychiatric diseases, an intelligence qu...

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Autores principales: Ni, Peiyan, Liu, Manli, Wang, Dequan, Tian, Yang, Zhao, Liansheng, Wei, Jinxue, Yu, Xueli, Qi, Xueyu, Li, Xiaojing, Yu, Hua, Ni, Rongjun, Ma, Xiaohong, Deng, Wei, Guo, Wanjun, Wang, Qiang, Li, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910219/
https://www.ncbi.nlm.nih.gov/pubmed/33654399
http://dx.doi.org/10.2147/NDT.S286102
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author Ni, Peiyan
Liu, Manli
Wang, Dequan
Tian, Yang
Zhao, Liansheng
Wei, Jinxue
Yu, Xueli
Qi, Xueyu
Li, Xiaojing
Yu, Hua
Ni, Rongjun
Ma, Xiaohong
Deng, Wei
Guo, Wanjun
Wang, Qiang
Li, Tao
author_facet Ni, Peiyan
Liu, Manli
Wang, Dequan
Tian, Yang
Zhao, Liansheng
Wei, Jinxue
Yu, Xueli
Qi, Xueyu
Li, Xiaojing
Yu, Hua
Ni, Rongjun
Ma, Xiaohong
Deng, Wei
Guo, Wanjun
Wang, Qiang
Li, Tao
author_sort Ni, Peiyan
collection PubMed
description INTRODUCTION: Schizophrenia, bipolar disorder (BD), and major depressive disorder are three common mental disorders. Although their diagnosis and treatment differ, they partially overlap. METHODS: To explore the similarities and characteristics of these three psychiatric diseases, an intelligence quotient (IQ) assessment was performed to evaluate cognitive deficits. Relative catechol-O-methyltransferase (COMT) expression in peripheral blood mononuclear cells was examined in all three groups compared with healthy controls (HCs). RESULTS: The results indicated that patients with any of the three psychiatric diseases presented IQ deficits, and that the first-episode schizophrenia (FES) group had even lower cognitive function than the other two groups. The relative COMT expression decreased in the FES group and increased in the BD group compared with the HC group. The correlation analysis of COMT expression level and IQ scores showed a positive correlation between relative COMT expression and full-scale IQ in the HC group. However, this correlation disappeared in all three psychiatric diseases studied. CONCLUSION: In conclusion, this cross-disease strategy provided important clues to explain lower IQ scores and dysregulated COMT expression among three common mental illnesses.
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spelling pubmed-79102192021-03-01 Association Analysis Between Catechol-O-Methyltransferase Expression and Cognitive Function in Patients with Schizophrenia, Bipolar Disorder, or Major Depression Ni, Peiyan Liu, Manli Wang, Dequan Tian, Yang Zhao, Liansheng Wei, Jinxue Yu, Xueli Qi, Xueyu Li, Xiaojing Yu, Hua Ni, Rongjun Ma, Xiaohong Deng, Wei Guo, Wanjun Wang, Qiang Li, Tao Neuropsychiatr Dis Treat Original Research INTRODUCTION: Schizophrenia, bipolar disorder (BD), and major depressive disorder are three common mental disorders. Although their diagnosis and treatment differ, they partially overlap. METHODS: To explore the similarities and characteristics of these three psychiatric diseases, an intelligence quotient (IQ) assessment was performed to evaluate cognitive deficits. Relative catechol-O-methyltransferase (COMT) expression in peripheral blood mononuclear cells was examined in all three groups compared with healthy controls (HCs). RESULTS: The results indicated that patients with any of the three psychiatric diseases presented IQ deficits, and that the first-episode schizophrenia (FES) group had even lower cognitive function than the other two groups. The relative COMT expression decreased in the FES group and increased in the BD group compared with the HC group. The correlation analysis of COMT expression level and IQ scores showed a positive correlation between relative COMT expression and full-scale IQ in the HC group. However, this correlation disappeared in all three psychiatric diseases studied. CONCLUSION: In conclusion, this cross-disease strategy provided important clues to explain lower IQ scores and dysregulated COMT expression among three common mental illnesses. Dove 2021-02-22 /pmc/articles/PMC7910219/ /pubmed/33654399 http://dx.doi.org/10.2147/NDT.S286102 Text en © 2021 Ni et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Ni, Peiyan
Liu, Manli
Wang, Dequan
Tian, Yang
Zhao, Liansheng
Wei, Jinxue
Yu, Xueli
Qi, Xueyu
Li, Xiaojing
Yu, Hua
Ni, Rongjun
Ma, Xiaohong
Deng, Wei
Guo, Wanjun
Wang, Qiang
Li, Tao
Association Analysis Between Catechol-O-Methyltransferase Expression and Cognitive Function in Patients with Schizophrenia, Bipolar Disorder, or Major Depression
title Association Analysis Between Catechol-O-Methyltransferase Expression and Cognitive Function in Patients with Schizophrenia, Bipolar Disorder, or Major Depression
title_full Association Analysis Between Catechol-O-Methyltransferase Expression and Cognitive Function in Patients with Schizophrenia, Bipolar Disorder, or Major Depression
title_fullStr Association Analysis Between Catechol-O-Methyltransferase Expression and Cognitive Function in Patients with Schizophrenia, Bipolar Disorder, or Major Depression
title_full_unstemmed Association Analysis Between Catechol-O-Methyltransferase Expression and Cognitive Function in Patients with Schizophrenia, Bipolar Disorder, or Major Depression
title_short Association Analysis Between Catechol-O-Methyltransferase Expression and Cognitive Function in Patients with Schizophrenia, Bipolar Disorder, or Major Depression
title_sort association analysis between catechol-o-methyltransferase expression and cognitive function in patients with schizophrenia, bipolar disorder, or major depression
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910219/
https://www.ncbi.nlm.nih.gov/pubmed/33654399
http://dx.doi.org/10.2147/NDT.S286102
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