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[(18)F]-JK-PSMA-7 PET/CT Under Androgen Deprivation Therapy in Advanced Prostate Cancer
PURPOSE: PSMA imaging is frequently used for monitoring of androgen deprivation therapy (ADT) in prostate cancer. In a previous study, [(18)F]-JK-PSMA-7 exhibited favorable properties for tumor localization after biochemical recurrence. In this retrospective study, we evaluated the performance of [(...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910246/ https://www.ncbi.nlm.nih.gov/pubmed/33006028 http://dx.doi.org/10.1007/s11307-020-01546-0 |
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author | Dietlein, Felix Mueller, Peter Kobe, Carsten Endepols, Heike Hohberg, Melanie Zlatopolskiy, Boris D. Krapf, Philipp Heidenreich, Axel Neumaier, Bernd Drzezga, Alexander Dietlein, Markus |
author_facet | Dietlein, Felix Mueller, Peter Kobe, Carsten Endepols, Heike Hohberg, Melanie Zlatopolskiy, Boris D. Krapf, Philipp Heidenreich, Axel Neumaier, Bernd Drzezga, Alexander Dietlein, Markus |
author_sort | Dietlein, Felix |
collection | PubMed |
description | PURPOSE: PSMA imaging is frequently used for monitoring of androgen deprivation therapy (ADT) in prostate cancer. In a previous study, [(18)F]-JK-PSMA-7 exhibited favorable properties for tumor localization after biochemical recurrence. In this retrospective study, we evaluated the performance of [(18)F]-JK-PSMA-7 under ADT. PROCEDURES: We examined the performance of [(18)F]-JK-PSMA-7 in 70 patients (first cohort) with increasing or detectable PSA values under ADT (PSA < 2 ng/ml for 21/70 patients). We further analyzed 58 independent patients with PSA levels < 2 ng/ml under ADT, who were imaged with [(68)Ga]PSMA-11 or [(18)F]DCFPyL (second cohort). Finally, we compared detection rates between [(18)F]-JK-PSMA-7, [(68)Ga]PSMA-11, and [(18)F]DCFPyL. RESULTS: In the first cohort, we detected [(18)F]-JK-PSMA-7-positive lesions in 63/70 patients. In patients with PSA levels ≥ 2 ng/ml, the detection rate was 100 % (49/49). In patients with PSA < 2 ng/ml, the detection rate was significantly lower (66.7 %, 14/21, p = 9.7 × 10(−5)) and dropped from 85.7 % (12/14, PSA levels between 0.3 and 2.0 ng/ml) to 28.6 % (2/7) for PSA levels < 0.3 ng/ml (p = 1.73 × 10(−2)). In the second cohort (PSA < 2 ng/ml), the detection rate was 79.3 % (46/58) for [(68)Ga]PSMA-11 or [(18)F]DCFPyL. Again, the detection rate was significantly higher (p = 1.1 × 10(−2)) for patients with PSA levels between 0.3 and 2.0 ng/ml (87.0 %, 40/46) relative to those with PSA levels < 0.3 ng/ml (50 %, 6/12). No significant difference was found between [(18)F]-JK-PSMA-7 and [(68)Ga]PSMA-11 or [(18)F]DCFPyL in patients with PSA levels < 2 ng/ml (p = 0.4295). CONCLUSION: [(18)F]-JK-PSMA-7 PET showed a high detection rate in patients with PSA levels ≥ 0.3 ng/ml under ADT. The lower PSA threshold of 0.3 ng/ml for high detection rates was consistent across the three PSMA ligands. Thus, PSMA imaging is suitable for clinical follow-up of patients with increasing PSA levels under ADT. |
format | Online Article Text |
id | pubmed-7910246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-79102462021-03-15 [(18)F]-JK-PSMA-7 PET/CT Under Androgen Deprivation Therapy in Advanced Prostate Cancer Dietlein, Felix Mueller, Peter Kobe, Carsten Endepols, Heike Hohberg, Melanie Zlatopolskiy, Boris D. Krapf, Philipp Heidenreich, Axel Neumaier, Bernd Drzezga, Alexander Dietlein, Markus Mol Imaging Biol Research Article PURPOSE: PSMA imaging is frequently used for monitoring of androgen deprivation therapy (ADT) in prostate cancer. In a previous study, [(18)F]-JK-PSMA-7 exhibited favorable properties for tumor localization after biochemical recurrence. In this retrospective study, we evaluated the performance of [(18)F]-JK-PSMA-7 under ADT. PROCEDURES: We examined the performance of [(18)F]-JK-PSMA-7 in 70 patients (first cohort) with increasing or detectable PSA values under ADT (PSA < 2 ng/ml for 21/70 patients). We further analyzed 58 independent patients with PSA levels < 2 ng/ml under ADT, who were imaged with [(68)Ga]PSMA-11 or [(18)F]DCFPyL (second cohort). Finally, we compared detection rates between [(18)F]-JK-PSMA-7, [(68)Ga]PSMA-11, and [(18)F]DCFPyL. RESULTS: In the first cohort, we detected [(18)F]-JK-PSMA-7-positive lesions in 63/70 patients. In patients with PSA levels ≥ 2 ng/ml, the detection rate was 100 % (49/49). In patients with PSA < 2 ng/ml, the detection rate was significantly lower (66.7 %, 14/21, p = 9.7 × 10(−5)) and dropped from 85.7 % (12/14, PSA levels between 0.3 and 2.0 ng/ml) to 28.6 % (2/7) for PSA levels < 0.3 ng/ml (p = 1.73 × 10(−2)). In the second cohort (PSA < 2 ng/ml), the detection rate was 79.3 % (46/58) for [(68)Ga]PSMA-11 or [(18)F]DCFPyL. Again, the detection rate was significantly higher (p = 1.1 × 10(−2)) for patients with PSA levels between 0.3 and 2.0 ng/ml (87.0 %, 40/46) relative to those with PSA levels < 0.3 ng/ml (50 %, 6/12). No significant difference was found between [(18)F]-JK-PSMA-7 and [(68)Ga]PSMA-11 or [(18)F]DCFPyL in patients with PSA levels < 2 ng/ml (p = 0.4295). CONCLUSION: [(18)F]-JK-PSMA-7 PET showed a high detection rate in patients with PSA levels ≥ 0.3 ng/ml under ADT. The lower PSA threshold of 0.3 ng/ml for high detection rates was consistent across the three PSMA ligands. Thus, PSMA imaging is suitable for clinical follow-up of patients with increasing PSA levels under ADT. Springer International Publishing 2020-10-01 2021 /pmc/articles/PMC7910246/ /pubmed/33006028 http://dx.doi.org/10.1007/s11307-020-01546-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Dietlein, Felix Mueller, Peter Kobe, Carsten Endepols, Heike Hohberg, Melanie Zlatopolskiy, Boris D. Krapf, Philipp Heidenreich, Axel Neumaier, Bernd Drzezga, Alexander Dietlein, Markus [(18)F]-JK-PSMA-7 PET/CT Under Androgen Deprivation Therapy in Advanced Prostate Cancer |
title | [(18)F]-JK-PSMA-7 PET/CT Under Androgen Deprivation Therapy in Advanced Prostate Cancer |
title_full | [(18)F]-JK-PSMA-7 PET/CT Under Androgen Deprivation Therapy in Advanced Prostate Cancer |
title_fullStr | [(18)F]-JK-PSMA-7 PET/CT Under Androgen Deprivation Therapy in Advanced Prostate Cancer |
title_full_unstemmed | [(18)F]-JK-PSMA-7 PET/CT Under Androgen Deprivation Therapy in Advanced Prostate Cancer |
title_short | [(18)F]-JK-PSMA-7 PET/CT Under Androgen Deprivation Therapy in Advanced Prostate Cancer |
title_sort | [(18)f]-jk-psma-7 pet/ct under androgen deprivation therapy in advanced prostate cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910246/ https://www.ncbi.nlm.nih.gov/pubmed/33006028 http://dx.doi.org/10.1007/s11307-020-01546-0 |
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