Aggresomes predict poor outcomes and implicate proteostasis in the pathogenesis of pediatric choroid plexus tumors

PURPOSE: Protein misfolding and aggregation result in proteotoxic stress and underlie the pathogenesis of many diseases. To overcome proteotoxicity, cells compartmentalize misfolded and aggregated proteins in different inclusion bodies. The aggresome is a paranuclear inclusion body that functions as...

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Detalles Bibliográficos
Autores principales: Amer, Nada, Taha, Hala, Hesham, Dina, Al-Shehaby, Nouran, Mosaab, Amal, Soudy, Mohamed, Osama, Aya, Mahmoud, Noura, Elayadi, Moatasem, Youssef, Ayda, Elbeltagy, Mohamed, Zaghloul, Mohamed Saad, Magdeldin, Sameh, Sayed, Ahmed A., El-Naggar, Shahenda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Laboratory Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910251/
https://www.ncbi.nlm.nih.gov/pubmed/33501605
http://dx.doi.org/10.1007/s11060-020-03694-3

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