Cargando…

High level of EZH2 expression is linked to high density of CD8-positive T-lymphocytes and an aggressive phenotype in renal cell carcinoma

PURPOSE: Enhancer of zeste homolog 2 (EZH2), the catalytic part of the Polycomb repressive complex 2 (PRC2), has a prognostic role in renal cell carcinoma (RCC) and was recently shown to modulate the immune response by reducing tumor cell immunogenicity. METHODS: To investigate whether the prognosti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eichenauer, Till, Simmendinger, Luca, Fraune, Christoph, Mandelkow, Tim, Blessin, Niclas C., Kluth, Martina, Hube-Magg, Claudia, Möller, Katharina, Clauditz, Till, Weidemann, Sören, Dahlem, Roland, Fisch, Margit, Riechardt, Silke, Simon, Ronald, Sauter, Guido, Büscheck, Franziska, Rink, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910252/ https://www.ncbi.nlm.nih.gov/pubmed/32303902 http://dx.doi.org/10.1007/s00345-020-03200-4

Ejemplares similares

Tumor cell PD-L1 expression is a strong predictor of unfavorable prognosis in immune checkpoint therapy-naive clear cell renal cell cancer
por: Möller, Katharina, et al.
Publicado: (2021)

Chromosome 17p13 deletion is associated with an aggressive tumor phenotype in clear cell renal cell carcinoma
por: Eichenauer, Till, et al.
Publicado: (2020)

Prevalence and clinical significance of VHL mutations and 3p25 deletions in renal tumor subtypes
por: Büscheck, Franziska, et al.
Publicado: (2020)

Y-chromosome loss is frequent in male renal tumors
por: Büscheck, Franziska, et al.
Publicado: (2021)

MMR Deficiency is Homogeneous in Pancreatic Carcinoma and Associated with High Density of Cd8-Positive Lymphocytes
por: Fraune, Christoph, et al.
Publicado: (2020)

Correction to: MMR Deficiency is Homogeneous in Pancreatic Carcinoma and Associated with High Density of Cd8-Positive Lymphocytes
por: Fraune, Christoph, et al.
Publicado: (2022)

A non-diploid DNA status is linked to poor prognosis in renal cell cancer
por: Büscheck, Franziska, et al.
Publicado: (2020)

p63 expression in human tumors and normal tissues: a tissue microarray study on 10,200 tumors
por: Steurer, Stefan, et al.
Publicado: (2021)

Prevalence of CD8(+) cytotoxic lymphocytes in human neoplasms
por: Blessin, Niclas C., et al.
Publicado: (2020)

Prevalence of proliferating CD8(+) cells in normal lymphatic tissues, inflammation and cancer
por: Blessin, Niclas C., et al.
Publicado: (2021)

DOG1 is commonly expressed in pancreatic adenocarcinoma but unrelated to cancer aggressiveness
por: Jansen, Kristina, et al.
Publicado: (2021)

Nomenclature and treatment of secondary urethral strictures following primary hypospadias repair: weighing up academic principles and clinical pragmatism
por: Vetterlein, Malte W., et al.
Publicado: (2020)

PD-L1 expression and CD8 positive lymphocytes in human neoplasms: A tissue microarray study on 11,838 tumor samples
por: Möller, Katharina, et al.
Publicado: (2023)

Large-Scale Tissue Microarray Evaluation Corroborates High Specificity of High-Level Arginase-1 Immunostaining for Hepatocellular Carcinoma
por: Lennartz, Maximilian, et al.
Publicado: (2021)

Napsin A Expression in Human Tumors and Normal Tissues
por: Weidemann, Sören, et al.
Publicado: (2021)

CELA3B immunostaining is a highly specific marker for acinar cell carcinoma of the pancreas
por: Uhlig, Ria, et al.
Publicado: (2023)

Carboxypeptidase A1 (CPA1) Immunohistochemistry Is Highly Sensitive and Specific for Acinar Cell Carcinoma (ACC) of the Pancreas
por: Uhlig, Ria, et al.
Publicado: (2022)

High prevalence of p16 staining in malignant tumors
por: De Wispelaere, Noémi, et al.
Publicado: (2022)

Homogeneous MMR Deficiency Throughout the Entire Tumor Mass Occurs in a Subset of Colorectal Neuroendocrine Carcinomas
por: Fraune, Christoph, et al.
Publicado: (2020)

Mismatch repair deficiency occurs very rarely in seminomas
por: Dum, David, et al.
Publicado: (2021)

Mesothelin Expression in Human Tumors: A Tissue Microarray Study on 12,679 Tumors
por: Weidemann, Sören, et al.
Publicado: (2021)

Diagnostic and prognostic impact of cytokeratin 18 expression in human tumors: a tissue microarray study on 11,952 tumors
por: Menz, Anne, et al.
Publicado: (2021)

High Homogeneity of Mesothelin Expression in Primary and Metastatic Ovarian Cancer
por: Weidemann, Sören, et al.
Publicado: (2023)

Loss of cytoplasmic survivin expression is an independent predictor of poor prognosis in radically operated prostate cancer patients
por: Büscheck, Franziska, et al.
Publicado: (2020)

Patterns of TIGIT Expression in Lymphatic Tissue, Inflammation, and Cancer
por: Blessin, Niclas C., et al.
Publicado: (2019)

Expression of the immune checkpoint receptor TIGIT in seminoma
por: Hinsch, Andrea, et al.
Publicado: (2019)

Semi-automated validation and quantification of CTLA-4 in 90 different tumor entities using multiple antibodies and artificial intelligence
por: Dum, David, et al.
Publicado: (2022)

BLEACH&STAIN 15-marker Multiplexed Imaging in 3,098 Human Carcinomas Reveals Six Major PD-L1–driven Immune Phenotypes with Distinct Spatial Orchestration
por: Bady, Elena, et al.
Publicado: (2023)

Angiotensin-Converting Enzyme 2 Protein Is Overexpressed in a Wide Range of Human Tumour Types: A Systematic Tissue Microarray Study on >15,000 Tumours
por: Meiners, Jan, et al.
Publicado: (2021)

E-Cadherin expression in human tumors: a tissue microarray study on 10,851 tumors
por: Burandt, Eike, et al.
Publicado: (2021)

Analysis of More than 16,000 Human Tumor and Normal Tissues Identifies Uroplakin 3B as a Useful Diagnostic Marker for Mesothelioma and Normal Mesothelial Cells
por: Lennartz, Maximilian, et al.
Publicado: (2022)

Cadherin-16 (CDH16) immunohistochemistry: a useful diagnostic tool for renal cell carcinoma and papillary carcinomas of the thyroid
por: Lennartz, Maximilian, et al.
Publicado: (2023)

High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer
por: Weidemann, Sören A., et al.
Publicado: (2019)

FABP1 expression in human tumors: a tissue microarray study on 17,071 tumors
por: Dum, David, et al.
Publicado: (2022)

Upregulation of the heterogeneous nuclear ribonucleoprotein hnRNPA1 is an independent predictor of early biochemical recurrence in TMPRSS2:ERG fusion-negative prostate cancers
por: Möller, Katharina, et al.
Publicado: (2020)

Prevalence of Syndecan-1 (CD138) Expression in Different Kinds of Human Tumors and Normal Tissues
por: Kind, Simon, et al.
Publicado: (2019)

Mammaglobin-A Expression Is Highly Specific for Tumors Derived from the Breast, the Female Genital Tract, and the Salivary Gland
por: Gorbokon, Natalia, et al.
Publicado: (2023)

Upregulation of SPDEF is associated with poor prognosis in prostate cancer
por: Meiners, Jan, et al.
Publicado: (2019)

High-Level γ-Glutamyl-Hydrolase (GGH) Expression is Linked to Poor Prognosis in ERG Negative Prostate Cancer
por: Melling, Nathaniel, et al.
Publicado: (2017)

Up regulation of the Hippo signalling effector YAP1 is linked to early biochemical recurrence in prostate cancers
por: Marx, Andreas, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_tsilmmp072uu91fgcnttlno5s2