Cargando…

Probing hepatic metabolism of [2-(13)C]dihydroxyacetone in vivo with (1)H-decoupled hyperpolarized (13)C-MR

OBJECTIVES: To enhance detection of the products of hyperpolarized [2-(13)C]dihydroxyacetone metabolism for assessment of three metabolic pathways in the liver in vivo. Hyperpolarized [2-(13)C]DHAc emerged as a promising substrate to follow gluconeogenesis, glycolysis and the glycerol pathways. Howe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marco-Rius, Irene, Wright, Alan J., Hu, De-en, Savic, Dragana, Miller, Jack J., Timm, Kerstin N., Tyler, Damian, Brindle, Kevin M., Comment, Arnaud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910257/ https://www.ncbi.nlm.nih.gov/pubmed/32910316 http://dx.doi.org/10.1007/s10334-020-00884-y

Ejemplares similares

Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized (13)C MR with Photosensitive Metabolic Substrates
por: Marco-Rius, Irene, et al.
Publicado: (2018)

Myocardial fatty acid metabolism probed with hyperpolarized [1-13C]octanoate
por: Yoshihara, Hikari, et al.
Publicado: (2015)

Hyperpolarized Dihydroxyacetone Is a Sensitive Probe of Hepatic Gluconeogenic State
por: Ragavan, Mukundan, et al.
Publicado: (2021)

Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-(13)C]Dehydroascorbic Acid Reduction Using (13)C Magnetic Resonance Spectroscopy
por: Timm, Kerstin N., et al.
Publicado: (2017)

Measuring changes in substrate utilization in the myocardium in response to fasting using hyperpolarized [1-(13)C]butyrate and [1-(13)C]pyruvate
por: Bastiaansen, Jessica A. M., et al.
Publicado: (2016)

A 3D hybrid-shot spiral sequence for hyperpolarized (13)C imaging
por: Tyler, Andrew, et al.
Publicado: (2021)

[(13)C]bicarbonate labelled from hyperpolarized [1-(13)C]pyruvate is an in vivo marker of hepatic gluconeogenesis in fasted state
por: Can, Emine, et al.
Publicado: (2022)

Real time measurement of myocardial substrate selection in vivo using hyperpolarized (13)C magnetic resonance
por: Bastiaansen, Jessica A, et al.
Publicado: (2015)

Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-(13)C]Pyruvate as Markers of Renal Gluconeogenesis
por: Yoshihara, Hikari A. I., et al.
Publicado: (2021)

(13)C magnetic resonance spectroscopy measurements with hyperpolarized [1‐(13)C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo
por: Dzien, Piotr, et al.
Publicado: (2015)

Hyperpolarized [1-(13)C]-Ascorbic and Dehydroascorbic Acid: Vitamin C as a Probe for Imaging Redox Status in Vivo
por: Bohndiek, Sarah E., et al.
Publicado: (2011)

Assessing ischemic myocardial metabolism in vivo with hyperpolarized 13C: relating the metabolic perturbation to the area at risk
por: Yoshihara, Hikari, et al.
Publicado: (2015)

Increased hyperpolarized [1‐(13)C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized (13)C‐labelled bicarbonate
por: Wright, Alan J., et al.
Publicado: (2018)

Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI
por: Wang, Jiazheng, et al.
Publicado: (2016)

Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized (13)C magnetic resonance
por: Mishkovsky, Mor, et al.
Publicado: (2017)

A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1‐(13)C]pyruvate and [1‐(13)C]lactate
por: Wang, Jiazheng, et al.
Publicado: (2017)

Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized (13)C-methylglyoxal
por: Shishmarev, Dmitry, et al.
Publicado: (2018)

Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized (13)C-substrates
por: Capozzi, Andrea, et al.
Publicado: (2017)

Probing Lactate Dehydrogenase Activity in Tumors by Measuring Hydrogen/Deuterium Exchange in Hyperpolarized l-[1-(13)C,U-(2)H]Lactate
por: Kennedy, Brett W. C., et al.
Publicado: (2012)

Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-(13)C]Pyruvate
por: Serrao, Eva M., et al.
Publicado: (2016)

Hyperpolarized (13)C MRI: Path to Clinical Translation in Oncology
por: Kurhanewicz, John, et al.
Publicado: (2018)

Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized (13)C magnetic resonance
por: Can, Emine, et al.
Publicado: (2020)

Magnetic resonance imaging of tumor glycolysis using hyperpolarized (13)C-labeled glucose
por: Rodrigues, Tiago B., et al.
Publicado: (2013)

Hyperpolarized (13)C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma
por: Mishkovsky, Mor, et al.
Publicado: (2021)

Hyperpolarized (13)C MRI: A novel approach for probing cerebral metabolism in health and neurological disease
por: Grist, James T, et al.
Publicado: (2020)

Quantifying normal human brain metabolism using hyperpolarized [1–(13)C]pyruvate and magnetic resonance imaging
por: Grist, James T., et al.
Publicado: (2019)

Detecting tumor responses to treatment using hyperpolarized (13)C magnetic resonance spectroscopic imaging
por: Brindle, Kevin M
Publicado: (2010)

Hyperpolarized (13)C magnetic resonance imaging for noninvasive assessment of tissue inflammation
por: Anderson, Stephanie, et al.
Publicado: (2020)

Hyperpolarized Carbon-13 MRI in Breast Cancer
por: Woitek, Ramona, et al.
Publicado: (2023)

Metabolic Effects of Doxorubicin on the Rat Liver Assessed With Hyperpolarized MRI and Metabolomics
por: Timm, Kerstin N., et al.
Publicado: (2022)

Probing Human Heart TCA Cycle Metabolism and Response to Glucose Load using Hyperpolarized [2-(13)C]Pyruvate MR Spectroscopy
por: Chen, Hsin-Yu, et al.
Publicado: (2023)

Cardiac perfusion imaging using hyperpolarized (13)c urea using flow sensitizing gradients
por: Lau, Angus Z., et al.
Publicado: (2015)

A comparison of quantitative methods for clinical imaging with hyperpolarized (13)C‐pyruvate
por: Daniels, Charlie J., et al.
Publicado: (2016)

In vivo investigation of hyperpolarized [1,3-(13)C(2)]acetoacetate as a metabolic probe in normal brain and in glioma
por: Najac, Chloé, et al.
Publicado: (2019)

Lactate saturation limits bicarbonate detection in hyperpolarized (13)C‐pyruvate MRI of the brain
por: Bøgh, Nikolaj, et al.
Publicado: (2022)

Mapping of intracellular pH in the in vivo rodent heart using hyperpolarized [1‐13C]pyruvate
por: Lau, Angus Z., et al.
Publicado: (2016)

Effects of fasting on serial measurements of hyperpolarized [1‐(13)C]pyruvate metabolism in tumors
por: Serrao, Eva M., et al.
Publicado: (2016)

Noninvasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized (13)C MRI
por: Rider, Oliver J., et al.
Publicado: (2020)

Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13)C-labeled cell metabolite and water protons
por: Marco-Rius, Irene, et al.
Publicado: (2014)

Comparison of (13)C MRI of hyperpolarized [1‐(13)C]pyruvate and lactate with the corresponding mass spectrometry images in a murine lymphoma model
por: Fala, Maria, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_h7ppjl5gienu9f3botfcnta3d0