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Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery
The purpose of this study is to compare the effect of the different physical factors on low-density lipoproteins (LDL) accumulation from flowing blood to the arterial wall of the left coronary arteries. The three-dimensional (3D) computational model of the left coronary arterial tree is reconstructe...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910311/ https://www.ncbi.nlm.nih.gov/pubmed/33637804 http://dx.doi.org/10.1038/s41598-021-84155-3 |
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author | Chen, Xueping Zhuang, Jian Huang, Huanlei Wu, Yueheng |
author_facet | Chen, Xueping Zhuang, Jian Huang, Huanlei Wu, Yueheng |
author_sort | Chen, Xueping |
collection | PubMed |
description | The purpose of this study is to compare the effect of the different physical factors on low-density lipoproteins (LDL) accumulation from flowing blood to the arterial wall of the left coronary arteries. The three-dimensional (3D) computational model of the left coronary arterial tree is reconstructed from a patient-specific computed tomography angiography (CTA) image. The endothelium of the coronary artery is represented by a shear stress dependent three-pore model. Fluid–structure interaction ([Formula: see text] ) based numerical method is used to study the LDL transport from vascular lumen into the arterial wall. The results show that the high elastic property of the arterial wall decreases the complexity of the local flow field in the coronary bifurcation system. The places of high levels of LDL uptake coincide with the regions of low wall shear stress. In addition, hypertension promotes LDL uptake from flowing blood in the arterial wall, while the thickened arterial wall decreases this process. The present computer strategy combining the methods of coronary CTA image 3D reconstruction, [Formula: see text] simulation, and three-pore modeling was illustrated to be effective on the simulation of the distribution and the uptake of LDL. This may have great potential for the early prediction of the local atherosclerosis lesion in the human left coronary artery. |
format | Online Article Text |
id | pubmed-7910311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79103112021-03-02 Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery Chen, Xueping Zhuang, Jian Huang, Huanlei Wu, Yueheng Sci Rep Article The purpose of this study is to compare the effect of the different physical factors on low-density lipoproteins (LDL) accumulation from flowing blood to the arterial wall of the left coronary arteries. The three-dimensional (3D) computational model of the left coronary arterial tree is reconstructed from a patient-specific computed tomography angiography (CTA) image. The endothelium of the coronary artery is represented by a shear stress dependent three-pore model. Fluid–structure interaction ([Formula: see text] ) based numerical method is used to study the LDL transport from vascular lumen into the arterial wall. The results show that the high elastic property of the arterial wall decreases the complexity of the local flow field in the coronary bifurcation system. The places of high levels of LDL uptake coincide with the regions of low wall shear stress. In addition, hypertension promotes LDL uptake from flowing blood in the arterial wall, while the thickened arterial wall decreases this process. The present computer strategy combining the methods of coronary CTA image 3D reconstruction, [Formula: see text] simulation, and three-pore modeling was illustrated to be effective on the simulation of the distribution and the uptake of LDL. This may have great potential for the early prediction of the local atherosclerosis lesion in the human left coronary artery. Nature Publishing Group UK 2021-02-26 /pmc/articles/PMC7910311/ /pubmed/33637804 http://dx.doi.org/10.1038/s41598-021-84155-3 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Chen, Xueping Zhuang, Jian Huang, Huanlei Wu, Yueheng Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery |
title | Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery |
title_full | Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery |
title_fullStr | Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery |
title_full_unstemmed | Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery |
title_short | Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery |
title_sort | fluid–structure interactions (fsi) based study of low-density lipoproteins (ldl) uptake in the left coronary artery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910311/ https://www.ncbi.nlm.nih.gov/pubmed/33637804 http://dx.doi.org/10.1038/s41598-021-84155-3 |
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