Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation

Many neurodegenerative diseases are associated with neuronal misfolded protein accumulation, indicating a need for proteostasis-promoting strategies. Here we show that de-repressing the transcription factor Nrf2, epigenetically shut-off in early neuronal development, can prevent protein aggregate ac...

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Detalles Bibliográficos
Autores principales: Baxter, Paul S., Márkus, Nóra M., Dando, Owen, He, Xin, Al-Mubarak, Bashayer R., Qiu, Jing, Hardingham, Giles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910424/
https://www.ncbi.nlm.nih.gov/pubmed/33637689
http://dx.doi.org/10.1038/s41419-021-03507-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910424/
https://www.ncbi.nlm.nih.gov/pubmed/33637689
http://dx.doi.org/10.1038/s41419-021-03507-z

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