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Catalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines

To increase the reliability and success rate of drug discovery, efforts have been made to increase the C(sp(3)) fraction and avoid flat molecules. sp(3)-Rich enantiopure amines are most frequently encountered as chiral auxiliaries, synthetic intermediates for pharmaceutical agents and bioactive natu...

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Detalles Bibliográficos
Autores principales:	Wang, Jia-Wang, Li, Yan, Nie, Wan, Chang, Zhe, Yu, Zi-An, Zhao, Yi-Fan, Lu, Xi, Fu, Yao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910428/ https://www.ncbi.nlm.nih.gov/pubmed/33637730 http://dx.doi.org/10.1038/s41467-021-21600-x

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