Cargando…

Specific PIP(2) binding promotes calcium activation of TMEM16A chloride channels

TMEM16A is a widely expressed Ca(2+)-activated Cl(−) channel that regulates crucial physiological functions including fluid secretion, neuronal excitability, and smooth muscle contraction. There is a critical need to understand the molecular mechanisms of TMEM16A gating and regulation. However, high...

Descripción completa

Detalles Bibliográficos
Autores principales: Jia, Zhiguang, Chen, Jianhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910439/
https://www.ncbi.nlm.nih.gov/pubmed/33637964
http://dx.doi.org/10.1038/s42003-021-01782-2