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Specific PIP(2) binding promotes calcium activation of TMEM16A chloride channels
TMEM16A is a widely expressed Ca(2+)-activated Cl(−) channel that regulates crucial physiological functions including fluid secretion, neuronal excitability, and smooth muscle contraction. There is a critical need to understand the molecular mechanisms of TMEM16A gating and regulation. However, high...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910439/ https://www.ncbi.nlm.nih.gov/pubmed/33637964 http://dx.doi.org/10.1038/s42003-021-01782-2 |