SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation

Our previous studies showed that silent mating-type information regulation 2 homologue-1 (SIRT1, a deacetylase) upregulation could attenuate sepsis-induced acute kidney injury (SAKI). Upregulated SIRT1 can deacetylate certain autophagy-related proteins (Beclin1, Atg5, Atg7 and LC3) in vitro. However...

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Detalles Bibliográficos
Autores principales: Deng, Zhiya, Sun, Maomao, Wu, Jie, Fang, Haihong, Cai, Shumin, An, Sheng, Huang, Qiaobing, Chen, Zhenfeng, Wu, Chenglun, Zhou, Ziwei, Hu, Haoran, Zeng, Zhenhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910451/
https://www.ncbi.nlm.nih.gov/pubmed/33637691
http://dx.doi.org/10.1038/s41419-021-03508-y

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