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The crosstalk between HIFs and mitochondrial dysfunctions in cancer development
Mitochondria are essential cellular organelles that are involved in regulating cellular energy, metabolism, survival, and proliferation. To some extent, cancer is a genetic and metabolic disease that is closely associated with mitochondrial dysfunction. Hypoxia-inducible factors (HIFs), which are ma...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910460/ https://www.ncbi.nlm.nih.gov/pubmed/33637686 http://dx.doi.org/10.1038/s41419-021-03505-1 |
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author | Bao, Xingting Zhang, Jinhua Huang, Guomin Yan, Junfang Xu, Caipeng Dou, Zhihui Sun, Chao Zhang, Hong |
author_facet | Bao, Xingting Zhang, Jinhua Huang, Guomin Yan, Junfang Xu, Caipeng Dou, Zhihui Sun, Chao Zhang, Hong |
author_sort | Bao, Xingting |
collection | PubMed |
description | Mitochondria are essential cellular organelles that are involved in regulating cellular energy, metabolism, survival, and proliferation. To some extent, cancer is a genetic and metabolic disease that is closely associated with mitochondrial dysfunction. Hypoxia-inducible factors (HIFs), which are major molecules that respond to hypoxia, play important roles in cancer development by participating in multiple processes, such as metabolism, proliferation, and angiogenesis. The Warburg phenomenon reflects a pseudo-hypoxic state that activates HIF-1α. In addition, a product of the Warburg effect, lactate, also induces HIF-1α. However, Warburg proposed that aerobic glycolysis occurs due to a defect in mitochondria. Moreover, both HIFs and mitochondrial dysfunction can lead to complex reprogramming of energy metabolism, including reduced mitochondrial oxidative metabolism, increased glucose uptake, and enhanced anaerobic glycolysis. Thus, there may be a connection between HIFs and mitochondrial dysfunction. In this review, we systematically discuss the crosstalk between HIFs and mitochondrial dysfunctions in cancer development. Above all, the stability and activity of HIFs are closely influenced by mitochondrial dysfunction related to tricarboxylic acid cycle, electron transport chain components, mitochondrial respiration, and mitochondrial-related proteins. Furthermore, activation of HIFs can lead to mitochondrial dysfunction by affecting multiple mitochondrial functions, including mitochondrial oxidative capacity, biogenesis, apoptosis, fission, and autophagy. In general, the regulation of tumorigenesis and development by HIFs and mitochondrial dysfunction are part of an extensive and cooperative network. |
format | Online Article Text |
id | pubmed-7910460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79104602021-03-04 The crosstalk between HIFs and mitochondrial dysfunctions in cancer development Bao, Xingting Zhang, Jinhua Huang, Guomin Yan, Junfang Xu, Caipeng Dou, Zhihui Sun, Chao Zhang, Hong Cell Death Dis Review Article Mitochondria are essential cellular organelles that are involved in regulating cellular energy, metabolism, survival, and proliferation. To some extent, cancer is a genetic and metabolic disease that is closely associated with mitochondrial dysfunction. Hypoxia-inducible factors (HIFs), which are major molecules that respond to hypoxia, play important roles in cancer development by participating in multiple processes, such as metabolism, proliferation, and angiogenesis. The Warburg phenomenon reflects a pseudo-hypoxic state that activates HIF-1α. In addition, a product of the Warburg effect, lactate, also induces HIF-1α. However, Warburg proposed that aerobic glycolysis occurs due to a defect in mitochondria. Moreover, both HIFs and mitochondrial dysfunction can lead to complex reprogramming of energy metabolism, including reduced mitochondrial oxidative metabolism, increased glucose uptake, and enhanced anaerobic glycolysis. Thus, there may be a connection between HIFs and mitochondrial dysfunction. In this review, we systematically discuss the crosstalk between HIFs and mitochondrial dysfunctions in cancer development. Above all, the stability and activity of HIFs are closely influenced by mitochondrial dysfunction related to tricarboxylic acid cycle, electron transport chain components, mitochondrial respiration, and mitochondrial-related proteins. Furthermore, activation of HIFs can lead to mitochondrial dysfunction by affecting multiple mitochondrial functions, including mitochondrial oxidative capacity, biogenesis, apoptosis, fission, and autophagy. In general, the regulation of tumorigenesis and development by HIFs and mitochondrial dysfunction are part of an extensive and cooperative network. Nature Publishing Group UK 2021-02-26 /pmc/articles/PMC7910460/ /pubmed/33637686 http://dx.doi.org/10.1038/s41419-021-03505-1 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Bao, Xingting Zhang, Jinhua Huang, Guomin Yan, Junfang Xu, Caipeng Dou, Zhihui Sun, Chao Zhang, Hong The crosstalk between HIFs and mitochondrial dysfunctions in cancer development |
title | The crosstalk between HIFs and mitochondrial dysfunctions in cancer development |
title_full | The crosstalk between HIFs and mitochondrial dysfunctions in cancer development |
title_fullStr | The crosstalk between HIFs and mitochondrial dysfunctions in cancer development |
title_full_unstemmed | The crosstalk between HIFs and mitochondrial dysfunctions in cancer development |
title_short | The crosstalk between HIFs and mitochondrial dysfunctions in cancer development |
title_sort | crosstalk between hifs and mitochondrial dysfunctions in cancer development |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910460/ https://www.ncbi.nlm.nih.gov/pubmed/33637686 http://dx.doi.org/10.1038/s41419-021-03505-1 |
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