Blastocyst complementation using Prdm14-deficient rats enables efficient germline transmission and generation of functional mouse spermatids in rats

Murine animal models from genetically modified pluripotent stem cells (PSCs) are essential for functional genomics and biomedical research, which require germline transmission for the establishment of colonies. However, the quality of PSCs, and donor-host cell competition in chimeras often present s...

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Detalles Bibliográficos
Autores principales: Kobayashi, Toshihiro, Goto, Teppei, Oikawa, Mami, Sanbo, Makoto, Yoshida, Fumika, Terada, Reiko, Niizeki, Naoko, Kajitani, Naoyo, Kazuki, Kanako, Kazuki, Yasuhiro, Hochi, Shinichi, Nakauchi, Hiromitsu, Surani, M. Azim, Hirabayashi, Masumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910474/
https://www.ncbi.nlm.nih.gov/pubmed/33637711
http://dx.doi.org/10.1038/s41467-021-21557-x

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